Macrophage Membrane Spontaneously Encapsulated Cyclodextrin-Based Nanomedicines for Improving Lipid Metabolism and Inflammation in Atherosclerosis

Atherosclerosis is a persistent inflammatory condition of the blood vessels associated with abnormalities in lipid metabolism. Development of biomimetic nanoplatforms provides an effective strategy. Herein, inspired by the peptide CLIKKPF spontaneously coupling to phosphatidylserine (PS) on the inne...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2024-09, Vol.16 (37), p.49660-49672
Main Authors: Mou, Nianlian, Duan, Xinmei, Qu, Kai, Chen, Qiao, He, Zhigui, Cao, Yu, Zhang, Kun, Qin, Xian, Zhu, Li, Han, ZhiQiang, Li, Chuanwei, Zhong, Yuan, Wu, Wei
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Atherosclerosis - pathology
Cell Membrane - drug effects
Cell Membrane - metabolism
Cyclodextrins - chemistry
Cyclodextrins - pharmacology
Functional Nanostructured Materials (including low-D carbon)
Humans
Inflammation - drug therapy
Inflammation - metabolism
Inflammation - pathology
Lipid Metabolism - drug effects
Macrophages - drug effects
Macrophages - metabolism
Mice
Nanomedicine
Nanoparticles - chemistry
RAW 264.7 Cells
Resveratrol - chemistry
Resveratrol - pharmacology
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Summary:Atherosclerosis is a persistent inflammatory condition of the blood vessels associated with abnormalities in lipid metabolism. Development of biomimetic nanoplatforms provides an effective strategy. Herein, inspired by the peptide CLIKKPF spontaneously coupling to phosphatidylserine (PS) on the inner leaflet of cell membranes specifically, MM@NPs were constructed by macrophage membrane spontaneous encapsulation of cyclodextrin-based nanoparticles modified with the peptide CLIKKPF and loaded with the hydrophobic compound resveratrol. MM@NPs could be specifically phagocytized by the activated endothelium with the overexpressed VCAM-1 for enhancing target delivery into the pathological lesion. Additionally, for the ApoE–/– mice, MM@NPs provide comprehensive treatment efficiency in reducing oxidant stress, alleviating the inherent inflammation, and decreasing cholesterol deposition, subsequently resulting in the atherosclerotic plaque regression. Therefore, MM@NPs could be one possible candidate for improving lipid metabolism and inflammation in atherosclerosis.
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/acsami.4c11370