Dimension compensation of printed master molds by a desktop LCD 3D printer for high-precision microfluidic applications

• Published in: Mikrochimica acta (1966) 2024-10, Vol.191 (10), p.583, Article 583
• Main Authors: Zhang, Xinjie, Liu, Yuyang, Bao, Yang, Zheng, Zixiao, Mi, Jian, Tang, Yuxin, Zhang, Qiwen, Oseyemi, Ayobami Elisha
• Format: Article
• Language: English
• Subjects: 3-D printers; Accuracy; Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Compensation; Cross-sections; Display devices; Errors; LCDs; Liquid crystal displays; Microchannels; Microengineering; Microfluidics; Molds; Nanochemistry; Nanotechnology; Optimization; Parameters; Photosensitivity; Polydimethylsiloxane; Three dimensional printing
• ISSN: 0026-3672; 1436-5073; 1436-5073
• DOI: 10.1007/s00604-024-06654-0

Recent advances in low-cost liquid crystal display (LCD) 3D printing have popularized its use in creating microfluidic master molds and complete devices. However, the quality and precision of these fabrications often fall short of the rigorous standards required for advanced microfluidic applications. This study introduces a novel approach to enhance the dimensional accuracy of microchannels produced using a desktop LCD 3D printer. We propose a method for dimension compensation, optimize the printing parameters, and provide a straightforward post-treatment technique to ensure high-quality curing of polydimethylsiloxane (PDMS) in master molds made from photosensitive resin. Our investigation assesses the precision of 3D printing across three different scales of square cross-section microchannels by measuring their widths and heights, leading to the determination of optimal printing parameters that minimize dimensional errors. The dimensional errors are further reduced by introducing a series of dimension compensation factors, which correct the nominal dimensions of the microchannels by using the compensation factors in 3D printing. The dimensional accuracy is significantly improved after compensation even in fabricating complex microchannels of triangular cross-sections. Finally, a spiral channel of trapezoidal-like cross-section with tilted edges is fabricated for microfluidic application, and highly efficient particle separation is realized in the channel. The proposed method provides new insights for utilizing desktop LCD 3D printers to achieve high-accuracy microstructures necessary for advanced microfluidic applications. Graphical Abstract