Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Limited research suggests that certain viruses reactivate in severe‐acute‐respiratory‐syndrome‐coronavirus 2 infection, contributing to the development of postacute sequelae of COVID‐19 (PASC). We examined 1083 infected individuals from a population‐based cohort, and assessed differences in plasma i...

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Bibliographic Details
Published in:Journal of medical virology 2024-09, Vol.96 (9), p.e29862-n/a
Main Authors: Karachaliou, Marianna, Ranzani, Otavio, Espinosa, Ana, Iraola‐Guzmán, Susana, Castaño‐Vinyals, Gemma, Vidal, Marta, Jiménez, Alfons, Bañuls, Marc, Nogués, Eva Alonso, Aguilar, Ruth, Garcia‐Aymerich, Judith, Cid, Rafael, Dobaño, Carlota, Moncunill, Gemma, Kogevinas, Manolis
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies
Antibodies, Viral - blood
Antibody Formation
Cohort Studies
Complications
Coronaviruses
COVID-19
COVID-19 - immunology
COVID-19 - virology
Cytomegalovirus
EBV early antigen
Female
herpesviruses
Humans
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin G - blood
long COVID
Male
Middle Aged
polyomaviruses
Post-Acute COVID-19 Syndrome
postacute sequelae of COVID‐19
Respiratory syncytial virus
SARS-CoV-2 - immunology
Severity of Illness Index
Varicella
Viral diseases
Viruses
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Summary:Limited research suggests that certain viruses reactivate in severe‐acute‐respiratory‐syndrome‐coronavirus 2 infection, contributing to the development of postacute sequelae of COVID‐19 (PASC). We examined 1083 infected individuals from a population‐based cohort, and assessed differences in plasma immunoglobulin (Ig)G and immunoglobulin A levels against Epstein‐Barr virus (EBV), cytomegalovirus, varicella zoster virus (VZV), BK polyomavirus, KI polyomavirus, WU polyomavirus (WUPyV), respiratory syncytial virus, and Adv‐36 according to the severity of previous COVID‐19 and PASC history. Individuals who had experienced severe COVID‐19 had higher antibody responses to latent viruses. Ever PASC, active persistent PASC, and PASC with neuropsychiatric symptoms were associated with higher immnoglobulin G to EBV early antigen‐diffuse, VZV, and WUPyV even among individuals without previous severe COVID‐19.
ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.29862