Carbonylation Reactions at Carbon‐Centered Radicals with an Adjacent Heteroatom

Heteroatoms are essential to living organisms and present in almost all molecules with medicinal usage. The catalytic functionalization at the carbon‐centered radical with an adjacent heteroatom provides an effective way to value added moiety while retaining the unique physicochemical and pharmacolo...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2024-12, Vol.63 (51), p.e202413374-n/a
Main Authors: Wang, Le‐Cheng, Wu, Xiao‐Feng
Format: Article
Language:English
Subjects:
alkenes
Boron
Carbon
carbon monoxide •carbonylation
Carbonyl compounds
Carbonyls
Chemical reactions
Chemical synthesis
Chlorine
Fine chemicals
Fluorine
Free radicals
Industrial development
Radicals
Reaction mechanisms
Silicon
Sulfur
synthetic methods
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Summary:Heteroatoms are essential to living organisms and present in almost all molecules with medicinal usage. The catalytic functionalization at the carbon‐centered radical with an adjacent heteroatom provides an effective way to value added moiety while retaining the unique physicochemical and pharmacological properties of heteroatoms, which can promote the development of pharmaceutical and fine chemical production. Carbonylative transformation was discovered nearly a century ago which is an efficient method for the synthesis of carbonyl‐containing molecules with potent applications in both industry and academia. Despite numerous advances in new reaction development, carbonylative transformation involving adjacent heteroatom carbon radical remain a subject that deserves to be discussed. In this minireview, we systematically summarized and discussed the recent advances in carbonylative transformations involving carbon‐centered radicals with an adjacent heteroatom, including oxygen (O), nitrogen (N), phosphorus (P), silicon (Si), sulfur (S), boron (B), fluorine (F), and chlorine (Cl). The related reaction mechanism was also discussed. This Minireview describes the most recent advances in carbonylative transformations involving heteroatom adjacent carbon radicals, specifically including the heteroatoms oxygen (O), nitrogen (N), phosphorus (P), silicon (Si), sulfur (S), boron (B), fluorine (F), and chlorine (Cl). The reaction mechanisms are also described in detail.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202413374