The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review

The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these antitumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradual cardiac failure. The production of free radicals that result in...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2024-09, Vol.41 (10), p.244, Article 244
Main Authors: Mohammad, Suleiman Ibrahim Shelash, Vasudevan, Asokan, Enwa, Felix Oghenemaro, Bansal, Jaya, Chahar, Mamata, Eldesoqui, Mamdouh, Ullah, Muhammad Ikram, Gardanova, Zhanna R., Hulail, Hanen Mahmod, Zwamel, Ahmed Hussein
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - adverse effects
Apoptosis
Cancer therapies
Cardiotoxicity
Cardiotoxicity - etiology
Cardiovascular disease
Chemotherapy
Drug therapy
Fatalities
Growth factors
Heart failure
Hematology
Humans
Hypertension
Inflammation
Internal Medicine
Medical laboratories
Medicine
Medicine & Public Health
Neoplasms - drug therapy
Neoplasms - metabolism
NF-E2-Related Factor 2 - metabolism
Oncology
Oxidative stress
Oxidative Stress - drug effects
Pathology
Pharmacy
Quality of life
Review Article
Risk factors
Side effects
Signal Transduction - drug effects
Sirtuin 1 - metabolism
Thromboembolism
Toxicity
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Summary:The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these antitumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradual cardiac failure. The production of free radicals that result in oxidative stress appears to be the key mechanism by which chemotherapy-induced cardiotoxicity (CIC) happens. Reports suggest that the Sirtuin-1 (Sirt1)/Nuclear factor E2-associated factor 2 (Nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. This review concludes recent knowledge about CIC with a special focus on the anti-oxidative regulation properties of the Sirt1/Nrf2 pathway.
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-024-02494-3