Alterations of the microbiome across body sites in systemic lupus erythematosus: A systematic review and meta-analysis

• Published in: Lupus 2024-10, Vol.33 (12), p.1345-1357
• Main Authors: Wang, Yiyu, Wu, Hong, Yan, Chengrui, Huang, Ronggui, Li, Kaidi, Du, Yujie, Jin, Xue, Zhu, Gaoqi, Zeng, Hanjun, Li, Baozhu
• Format: Article
• Language: English
• Subjects: Autoimmune diseases; Bacteria - classification; Bacteria - isolation & purification; Diversity indices; Dysbacteriosis; Dysbiosis - microbiology; Gastrointestinal Microbiome; Geographical variations; Humans; Intestinal microflora; Lupus; Lupus Erythematosus, Systemic - microbiology; Meta-analysis; Microbiomes; Microbiota; Microorganisms; Mouth - microbiology; Oral cavity; Pathogenesis; Skin - microbiology; Systemic lupus erythematosus
• ISSN: 0961-2033; 1477-0962; 1477-0962
• DOI: 10.1177/09612033241281891

Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unclear etiology. Growing evidence suggests the microbiome plays a role in SLE pathogenesis. However, findings are inconsistent across studies due to factors like small sample sizes and geographical variations. A comprehensive meta-analysis is needed to elucidate microbiome alterations in SLE. Objective This study aimed to provide a systematic overview of microbiota dysbiosis across body sites in SLE through a meta-analysis of alpha diversity indices, beta diversity indices, and abundance taxa of microbiome. Methods A literature search was conducted across four databases to identify relevant studies comparing SLE patients and healthy controls. Extracted data encompassed alpha and beta diversity metrics, as well as bacterial, fungal, and viral abundance across gut, oral, skin, and other microbiota. Study quality was assessed using the Newcastle-Ottawa Scale. Standardized mean differences and pooled effect sizes were calculated through meta-analytical methods. Results The analysis showed reduced alpha diversity and distinct beta diversity in SLE, particularly in the gut microbiota. Taxonomic analysis revealed compositional variations in bacteria from the gut and oral cavity. However, results for fungi, viruses, and bacteria from other sites were inconsistent due to limited studies. Conclusions This meta-analysis offers a comprehensive perspective on microbiome dysbiosis in SLE patients across diverse body sites and taxa. The observed variations underscore the microbiome’s potential role in SLE pathogenesis. Future research should address geographical variations, employ longitudinal designs, and integrate multi-omics approaches.