The interplay between oxidative stress, zinc, and metabolic dysfunction in polycystic ovarian syndrome

• Published in: Molecular and cellular biochemistry 2024-09
• Main Authors: Camp, Olivia G, Moussa, Daniel N, Hsu, Richard, Awonuga, Awoniyi O, Abu-Soud, Husam M
• Format: Article
• Language: English
• ISSN: 0300-8177; 1573-4919; 1573-4919
• DOI: 10.1007/s11010-024-05113-x

Polycystic ovarian syndrome (PCOS) is a functional endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology that has been associated with chronic disease and comorbidities including adverse metabolic and cardiac disorders. This review aims to evaluate the role of oxidative stress and zinc in the metabolic dysfunction observed in PCOS, with a focus on insulin resistance. Recent studies indicate that oxidative stress markers are elevated in PCOS and correlate with hyperandrogenemia, obesity, and insulin resistance. Zinc, an essential trace element, is crucial for metabolic processes, particularly in the pancreas for beta-cell function and glucagon secretion. Insufficient zinc levels have been linked to diabetes, obesity, and lipid metabolism disorders. This review aims to highlight the interplay between oxidative stress, zinc, and metabolic dysfunction in PCOS, suggesting that zinc supplementation could mitigate some metabolic and endocrine manifestations of PCOS.