Receptive-field nonlinearities in primary auditory cortex: a comparative perspective

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-09, Vol.34 (9)
• Main Authors: Homma, Natsumi Y, See, Jermyn Z, Atencio, Craig A, Hu, Congcong, Downer, Joshua D, Beitel, Ralph E, Cheung, Steven W, Najafabadi, Mina Sadeghi, Olsen, Timothy, Bigelow, James, Hasenstaub, Andrea R, Malone, Brian J, Schreiner, Christoph E
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation - methods; Action Potentials - physiology; Animals; Auditory Cortex - physiology; Auditory Perception - physiology; Cats; Female; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons - physiology; Rats; Saimiri; Species Specificity
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhae364

Abstract Cortical processing of auditory information can be affected by interspecies differences as well as brain states. Here we compare multifeature spectro-temporal receptive fields (STRFs) and associated input/output functions or nonlinearities (NLs) of neurons in primary auditory cortex (AC) of four mammalian species. Single-unit recordings were performed in awake animals (female squirrel monkeys, female, and male mice) and anesthetized animals (female squirrel monkeys, rats, and cats). Neuronal responses were modeled as consisting of two STRFs and their associated NLs. The NLs for the STRF with the highest information content show a broad distribution between linear and quadratic forms. In awake animals, we find a higher percentage of quadratic-like NLs as opposed to more linear NLs in anesthetized animals. Moderate sex differences of the shape of NLs were observed between male and female unanesthetized mice. This indicates that the core AC possesses a rich variety of potential computations, particularly in awake animals, suggesting that multiple computational algorithms are at play to enable the auditory system’s robust recognition of auditory events.