Development of pharmacy-based best practices to support safer use and management of prescription opioids based on an e-Delphi methodology

• Published in: Research in social and administrative pharmacy 2024-12, Vol.20 (12), p.1110-1117
• Main Authors: Nielsen, Suzanne, Horn, Freya, McDonald, Rebecca, Eide, Desiree, Walley, Alexander Y, Binswanger, Ingrid, Langford, Aili V, Prathivadi, Pallavi, Wood, Pene, Clausen, Thomas, Picco, Louisa
• Format: Article
• Language: English
• Subjects: Adult; Analgesics; Analgesics, Opioid - adverse effects; Analgesics, Opioid - therapeutic use; Community Pharmacy Services - organization & administration; Community Pharmacy Services - standards; Consensus; Delphi Technique; e-Delphi; Female; Humans; Male; Middle Aged; Naloxone; Opioid; Opioid-Related Disorders - drug therapy; Opioid-Related Disorders - prevention & control; Overdose; Pharmacies; Pharmacists - organization & administration; Practice Guidelines as Topic; Prescription drugs; Qualitative
• ISSN: 1551-7411; 1934-8150; 1934-8150
• DOI: 10.1016/j.sapharm.2024.09.001

Opioid utilization and related harm have increased in recent decades, notably in Australia, the United States, Canada, and some European countries. For people who are prescribed opioids, pharmacies offer an accessible, regular point-of-contact, providing a unique opportunity to address opioid prescription drugs risks. This project aimed to develop consensus-based, best practice statements for improving the safer use of prescription opioids through community pharmacy settings. The e-Delphi technique is used to obtain consensus from experts about issues where conclusive evidence is lacking, using multiple rounds of online participation. The investigator group identified an international group of potential participants with relevant expertise who were invited to the study, and asked to identify other experts for invitation. The e-Delphi process comprised three online rounds, involving (1) statement idea generation, (2) developing statement consensus, and (3) confirming and ranking statements. A diverse group of 42 experts (76 % female, 6 countries) participated, comprising pharmacists (n = 24, 57 %), medical doctors of differing specialties (n = 12, 29 %), and/or researchers (n = 28, 67 %), with a mean of 15 years’ professional experience (SD = 8.08). Eighty-five statements were initially developed in Round 1, and 78 were supported with amendments, with suggestions to merge and remove items in Round 2, resulting in 72 final statements which were all endorsed in Round 3. Items spanned seven themes: education, monitoring outcomes and risk, deprescribing and pain management, overdose education and naloxone, opioid agonist treatment, staff education, and overarching practices. Preferred terminology was determined in Round 2 and confirmed in Round 3. Community pharmacies offer a unique opportunity to support the safer use of prescription opioids. These 72 best practice statements provide practical guidance on specific practices that pharmacists can undertake to support patients' safer use of prescription opioids and prevent or reduce harms from prescribed opioid use. •We developed 72 best practices to improve prescription opioid safety in pharmacies.•These practices were developed using a three-stage, e-Delphi approach.•Project drew on 42 international experts, from pharmacy, medicine, and academia.•Practices cover education, outcomes and risk, pain, overdose, and opioid agonists.•Pharmacists undertaking these practices will improve safe use of prescribed opioids.