Association of probiotics, prebiotics, synbiotics or yogurt supplement with prevalence and all-cause mortality of depression: NHANES 2005–2016

• Published in: Journal of affective disorders 2025-01, Vol.368, p.547-554
• Main Authors: Ye, Zhijun, Yu, Shiyao, Yang, Yunxiang, Li, Shumin, Li, Sheng, Ma, Rui, Fu, Wenbin, Li, Xiangguang, Luo, Ding
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cross-Sectional Studies; Depression; Depression - epidemiology; Dietary Supplements - statistics & numerical data; Female; Humans; Male; Middle Aged; NHANES findings; Nutrition Surveys; Prebiotics; Prebiotics - administration & dosage; Prevalence; Probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; Synbiotics; Synbiotics - administration & dosage; United States - epidemiology; Yogurt; Young Adult
• ISSN: 0165-0327; 1573-2517; 1573-2517
• DOI: 10.1016/j.jad.2024.09.034

A growing body of studies revealed that enteric dysbacteriosis could result in depression via the “gut–microbiota–brain axis” (GMBA). Whether probiotics, prebiotics, and synbiotics supplements could lessen the risk of depression is a topic attracting attention. This research was conducted to evaluate the relationship between probiotics, prebiotics, synbiotics, or yogurt supplements and depression with large cross-sectional data. All data in our research was sourced from the National Health and Nutrition Examination Survey (NHANES) (2005–2016). Probiotics, prebiotics, synbiotics, and yogurt supplements were identified using Food Frequency Questionnaire (FFQ) and Dietary Supplement Use 30-Day (DSQ). We employed the Patient Health Questionnaire (PHQ-9) for evaluating depression. Logistic regression and the Kaplan-Meier curve were performed to examine the correlation between the supplements and depression, as well as mortality. A total of 17,745 adult participants were selected. The participants who supplemented probiotics, prebiotics, synbiotics, or yogurt products in the last 30 days showed a significantly lower depression rate compared with those who didn't. Specifically, the supplements could alleviate depressive symptoms including sad, anhedonia, sleep problems, fatigue, appetite changes, and psychomotor changes. This association was more prominent in specific populations such as the population aged 40–60 years, male, whites. The supplements also show more significant effects on increasing survival rates in patients with mild depression. Cross-sectional analysis reveals correlative but not causative association. Based on the analysis of NHANES data, our research highlights the positive effect the supplements have on preventing depression, relieving depressive symptoms and increasing survival rates. This effect varied across populations. •The main conclusions of this large cross-sectional study were still established after thorough adjustment for covariates.•Probiotic supplements could significantly reduce the prevalence of depression, increase survival rates and alleviate depressive symptoms.•Interaction effects showed more significant beneficial efforts on reducing depression in specific populations.