Osseointegration and Histopathological Evaluation of Titanium–Titanium Diboride Composite Compared to Pure Titanium Implant Materials Prepared by Powder Metallurgy (In Vivo Study)

ABSTRACT The efficacy and osseointegration rate of an implant depend on its biocompatibility. Modern implantology seeks fast and reliable osseointegration, which is essential for clinical success. The objective of this research was to assess the osseointegration and biocompatibility of a titanium–ti...

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Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2024-10, Vol.112 (10), p.e35490-n/a
Main Authors: Aljafery, Ali Mohammad Ali, Fatalla, Abdalbseet A., Haider, Julfikar
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Bone growth
Bone healing
Bone histomorphometry
Bone implants
dental implant
Healing
Histology
histopathology
Implants, Experimental
In vivo methods and tests
Male
Materials Testing
Metallurgical analysis
Metallurgy
Osseointegration
Osteocytes
Osteogenesis
Osteoid
Powder metallurgy
Powders
Rabbits
Shear strength
Surgical implants
Tibia
Tibia - pathology
Time measurement
Titanium
Titanium - chemistry
Titanium diboride
Ti‐TIB2
Transplants & implants
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Summary:ABSTRACT The efficacy and osseointegration rate of an implant depend on its biocompatibility. Modern implantology seeks fast and reliable osseointegration, which is essential for clinical success. The objective of this research was to assess the osseointegration and biocompatibility of a titanium–titanium diboride composite (Ti‐TiB2) in rabbits in contrast to those of pure titanium (Ti). A total of 64 cylindrical implant specimens were fabricated, consisting of two sets: pure Ti (32 implants) and Ti‐TiB2 composite (32 implants). In this study, two implants were implanted per tibia (left and right tibias) in 16 white male New Zealand rabbits, for a total of four implants per rabbit (4 × 16 = 64 implants). A pushout test was used to assess implant specimen‐bone bonding after 2 and 6 weeks of healing. The experiment utilized five rabbits per healing phase, which means that 20 implants per time point were used for the pushout tests. (10 for pure Ti and 10 for the composite). Histology was used to examine the tissue response to biocompatibility, and histomorphometry was used to measure new bone growth at the two time points. With three rabbits per time point, 12 implants were employed for the histological analyses. After implantation, the pushout shear strength results revealed that the mean shear strength of the Ti‐TiB2 implant specimens (5.4 ± 0.029 MPa for 2 weeks, 7.9 ± 0.029 MPa for 6 weeks) was statistically greater (p 
ISSN:1552-4973
1552-4981
1552-4981
DOI:10.1002/jbm.b.35490