Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study

• Published in: Neuropsychological rehabilitation 2024-09, p.1-17
• Main Authors: Rioux, Mathilde, Brasher, Penelope M A, McKeown, Gabriel, Yeates, Keith Owen, Vranceanu, Ana-Maria, Snell, Deborah L, Cairncross, Molly, Panenka, William J, Iverson, Grant L, Debert, Chantel T, Bayley, Mark T, Hunt, Cindy, Burke, Matthew J, Silverberg, Noah D
• Format: Article
• Language: English
• ISSN: 0960-2011; 1464-0694; 1464-0694
• DOI: 10.1080/09602011.2024.2403647

Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials. The GET + UC group (N = 34) received GET (delivered over 16 videoconference sessions) in addition to usual care (UC). The historical comparison group (N = 71) received UC only. PCS severity (Rivermead Post Concussion Symptoms Questionnaire; RPQ) and disability (World Health Organization Disability Assessment Schedule; WHODAS 2.0 12-item) were measured at clinic intake (M = 2.7, SD = 1.1 months after injury) and again at M = 4.9 (SD = 1.1) months after injury. Between-group differences were estimated using linear mixed effects regression, with a sensitivity analysis controlling for injury-to-assessment intervals. The estimated average change on the RPQ was -14.3 in the GET + UC group and -5.3 in the UC group. The estimated average change on the WHODAS was -5.3 in the GET + UC group and -3.2 in the UC group. Between-group differences post-treatment were -5.3 on the RPQ and -1.5 on the WHODAS. Treatment effects were larger in sensitivity analyses. Findings suggest that a randomized controlled trial is warranted.