Exploring the biological responses involved in the genetic resistance to Rhipicephalus microplus in Argentine Creole cattle

• Published in: Tropical animal health and production 2024-11, Vol.56 (8), p.289, Article 289
• Main Authors: Ortega, María Florencia, Bonamy, Martín, Cutullé, Christian, Giovambattista, Guillermo
• Format: Article
• Language: English
• Subjects: Animals; Arachnids; Argentina; Biomedical and Life Sciences; Blood coagulation; Cattle; Cattle - genetics; Cattle Diseases - genetics; Cattle Diseases - immunology; Cattle Diseases - parasitology; Chromosome Mapping - veterinary; Chromosomes; Control programs; Density; Disease Resistance - genetics; Disease transmission; DNA microarrays; Female; Gene mapping; Genetics; Genotype; Genotyping; Immune system; Information processing; Life Sciences; Livestock; Livestock production; Phosphorylation; Population genetics; Population studies; Quantitative Trait Loci; Regeneration (physiology); Regular Articles; Rhipicephalus - genetics; Rhipicephalus - physiology; Rhipicephalus microplus; Tick Infestations - parasitology; Tick Infestations - veterinary; Ticks; Tissue engineering; Veterinary Medicine/Veterinary Science; Zoology
• ISSN: 0049-4747; 1573-7438; 1573-7438
• DOI: 10.1007/s11250-024-04110-y

The common cattle tick Rhipicephalus microplus causes severe limitations to livestock production. Bovine genetics could be a decisive component for the success or failure of control programs for ticks and diseases transmitted. The objective of this work was to detect chromosomal regions associated with host resistance to R. microplus through an associative mapping study using medium and high density microarrays in a population of Argentine Creole cattle. The phenotypic record of the number of ticks that completed their development on the host, after artificial infestations, was obtained during 2015 to 2020. Genomic DNA was extracted for genotyping from 192 animals using Affymetrix high (Axiom™ Bos 1) and medium density (ArBos1) microarrays. In an exploratory study, chromosomal regions containing putative quantitative trait loci (QTLs) were recognized on chromosomes 27, 11, 10, 9, 16, 13, 3, 19, 8 and 18, associated with the variation of R. microplus load. Gene ontology based on genes located on these regions revealed an enrichment of terms and pathways for the immune system, blood coagulation, tissue regeneration, endopeptidase activity and protein phosphorylation. The information obtained in this work constitutes a first report of QTLs for tick count in the Argentine Creole cattle, and contributes with the knowledge about the underlying process involved in tick resistance.