Causal effect of air pollution on the risk of brain health and potential mediation by gut microbiota

Epidemiologic investigations have examined the correlation between air pollution and neurologic disorders and neuroanatomic structures. Increasing evidence underscores the profound influence of the gut microbiota on brain health. However, the existing evidence is equivocal, and a causal link remains...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2024-10, Vol.285, p.117080, Article 117080
Main Authors: Zhou, Xingwang, Guo, Zhengshan, Ling, Yuanguo, Teng, Wei, Cui, Junshuan, Yan, Zhangwei, Hou, Xianwen, Cen, Wu, Long, Niya, Li, Wenyan, Yang, Hua, Chu, Liangzhao
Format: Article
Language:English
Subjects:
Brain health
Brain structures
Gut microbiota
Mendelian randomization
Multiple sclerosis
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Summary:Epidemiologic investigations have examined the correlation between air pollution and neurologic disorders and neuroanatomic structures. Increasing evidence underscores the profound influence of the gut microbiota on brain health. However, the existing evidence is equivocal, and a causal link remains uncertain. This study aimed: to determine if there is a causal connection between four key air pollutants, and 42 neurologic diseases, and 1325 distinct brain structures; and to explore the potential role of the gut microbiota in mediating these associations. Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) models were deployed to estimate the causal impact of air pollutants (including particulate matter [PM] with aerodynamic diameters
ISSN:0147-6513
1090-2414
1090-2414
DOI:10.1016/j.ecoenv.2024.117080