Epidemiology and timing of infectious complications from battlefield-related burn injuries

• Published in: Burns 2024-12, Vol.50 (9), p.107200, Article 107200
• Main Authors: Geringer, Matthew R., Stewart, Laveta, Shaikh, Faraz, Carson, M. Leigh, Lu, Dan, Cancio, Leopoldo C., Gurney, Jennifer M., Tribble, David R., Kiley, John L.
• Format: Article
• Language: English
• Subjects: Adult; Afghan Campaign 2001; Bacteremia - epidemiology; Blast Injuries - complications; Blast Injuries - epidemiology; Body Surface Area; Burn infections; Burns; Burns - complications; Burns - epidemiology; Female; Humans; Invasive fungal infections; Iraq War, 2003-2011; Male; Military; Military Personnel - statistics & numerical data; Multidrug-resistant infections; Pneumonia - epidemiology; Pneumonia - etiology; Sepsis - epidemiology; Sepsis - etiology; Soft Tissue Infections - epidemiology; Soft Tissue Infections - microbiology; Time Factors; United States - epidemiology; War-Related Injuries - complications; War-Related Injuries - epidemiology; Wound Infection - epidemiology; Wound Infection - microbiology; Wound infections; Young Adult
• ISSN: 0305-4179; 1879-1409; 1879-1409
• DOI: 10.1016/j.burns.2024.07.004

Infections are the most frequent complication and cause of mortality in burn patients. We describe the epidemiology and outcomes of infections among deployed U.S. military personnel with burns. Military personnel who sustained a burn injury in Iraq or Afghanistan (2009–2014) and were admitted to the Burn Center at U.S. Army Institute of Surgical Research at Brooke Army Medical Center were included in the analysis. The study population included 144 patients who were primarily young (median 24 years) males (99 %) with combat-related burns (62 %) sustained via a blast (57 %), resulting in a median total body surface area burned (TBSA) of 6 % (IQR 3–14 %). Twenty-six (18 %) patients developed infections, with pneumonia being the predominant initial infection (= 16), followed by skin and soft-tissue infections (SSTI, = 6), bloodstream infections (BSI, = 3), and intra-abdominal infections (IAI, = 1). Initial infections were diagnosed at a median of 4 days (IQR 3–5) post-injury for pneumonia, 7 days (IQR 4–12) for SSTIs, 7 days (IQR 6–7) for BSI, and 17 days for IAI. Patients with infections were more severely injured with greater TBSA (median 31 % vs 5 %), more inhalation injury (38 % vs 12 %), and longer time to definitive surgical management (median of 34 days vs 9) compared to those who did not develop infections (p