Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD)

A comprehensive and accessible Herpesvirus drug resistance database was designed to serve as an international reference for diagnosis and clinical studies. This database available at https://www.unilim.fr/cnr-herpesvirus/outils/codexmv/includes both resistance-related mutations and natural polymorph...

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Bibliographic Details
Published in:Antiviral research 2024-11, Vol.231, p.106016, Article 106016
Main Authors: Tilloy, Valentin, Díaz-González, Daniel, Laplace, Lisa, Bisserier, Emilien, Chou, Sunwen, Rawlinson, William D., Boivin, Guy, Baldanti, Fausto, Lazzarotto, Tiziana, Andrei, Graciela, Hirsch, Hans H., Marcos, María Ángeles, Michel, Detlef, Hantz, Sébastien, Alain, Sophie
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Antivirals
Cytomegalovirus
Databases, Genetic
Drug Resistance, Viral - genetics
Genotype
Herpesviridae - drug effects
Herpesviridae - genetics
Herpesviridae Infections - virology
Humans
Mutation
Polymorphisms
Resistance
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Summary:A comprehensive and accessible Herpesvirus drug resistance database was designed to serve as an international reference for diagnosis and clinical studies. This database available at https://www.unilim.fr/cnr-herpesvirus/outils/codexmv/includes both resistance-related mutations and natural polymorphisms. Initially designed for human cytomegalovirus, it will be expanded to include herpes simplex and varicella-zoster viruses. Newly published mutations and new mutations reported by users or collaborating expert laboratories will be reviewed by an international committee of reference laboratories before inclusion in the database. Coupled with the Herpesvirus Sequence Analysis tool (HSA) mutation reports from NGS or Sanger sequences, it will be an open source for researchers in the field of Herpesviruses. We hope to fill this unmet need for the development and standardization of resistance genotyping. •From “Comprehensive Herpesviruses Antiviral Resistance Mutation Database (CHARMD)".•Open source Herpesvirus drug resistance database.•Includes both resistance-related mutations and natural polymorphisms.•Designed to serve as international reference regularly reviewed by an international committee.•HSA included tool generates a standardized mutation report from submitted sequences.
ISSN:0166-3542
1872-9096
1872-9096
DOI:10.1016/j.antiviral.2024.106016