Polysomnographic and clinical characteristics of sleep apnea headache patients

• Published in: Sleep & breathing 2024-12, Vol.28 (6), p.2591-2596
• Main Authors: Sunbul, Esra Aydin, Karacı, Rahşan, Karabulut, Elif Gözde Türedi, Güleç, Hüseyin, Domaç, Füsun Mayda
• Format: Article
• Language: English
• Subjects: Adult; Apnea; Dentistry; Female; Headache; Headache - diagnosis; Headache - physiopathology; Headaches; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Otorhinolaryngology; Pain perception; Patients; Pediatrics; Pneumology/Respiratory System; Polysomnography; Population studies; Retrospective Studies; Sleep and wakefulness; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - physiopathology; Sleep Breathing Physiology and Disorders • Original Article; Sleep disorders; Titration
• ISSN: 1520-9512; 1522-1709; 1522-1709
• DOI: 10.1007/s11325-024-03117-x

Purpose Sleep apnea headache can be defined as a persistent, widespread, throbbing headache that occurs recurrently, is not accompanied by any additional symptoms after waking up, and usually resolves within four hours. Diagnosis of the condition requires confirmation through polysomnography with an apnea-hypopnea index of at least 5, indicating the presence of obstructive sleep apnea syndrome (OSAS). While sleep apnea headaches are common in 10–15% of individuals with OSAS, morning headaches are experienced by 5% of this population. The aim of this study is to examine both polysomnographic and clinical features associated with sleep apnea headache in individuals confirmed to have OSAS by polysomnography. Method The study was conducted in the sleep center of University of Health Science, Erenköy Mental and Nervous Disease Training and Research Hospital. We have examined the clinical and polysomnographic data of the patients with sleep apnea headache (SAH) diagnosed according to IHS-3 criteria retrospectively and grouped the patients as mild, moderate and severe OSAS. Patients with morning headache except sleep apnea headache and under PAP titration treatment were excluded. The differences between the sleep macro structures of patients with (WSAH) and without sleep apnea headache (WOSAH) were examined. Results The WSAH group consisted of 384 participants and the control group (WOSAH) consisted of 294 participants The mean age was 46.29 ± 12.18 and 45.08 ± 12.62 years, respectively. Patients in the WSAH group had significantly higher scores on the Epworth Sleepiness Scale (ESS) ( p  = 0.004) and higher periodic limb movement index (PLMI) ( p  = 0.014) compared to the WOSAH group. WSAH patients exhibited shorter wake times after sleep onset (WASO) and lower scores on the sleep quality index, in contrast to WOSAH patients. Additionally, within the WSAH group, there was a negative correlation between age and several sleep parameters, including total sleep parameters. A positive correlation was observed between sleep duration ( p  = 0.009), waking up after sleep ( p  = 0.043), sleep efficiency ( p  = 0.001) and apnea-hypopnea index (AHI) ( p  = 0.018). Additionally, ESS scores were positively correlated with AHI and total awake time ( p  = 0.000 and p  = 0.008, respectively), while negatively correlated with stage N3 sleep percentage and mean minimum oxygen level ( p  = 0.001 and p  = 0.020, respectively) in the WSAH group. Conclusion The causes and possible mec