Cold atmospheric plasma as a promising tool in treatment of Trichophyton rubrum-induced skin infection in a guinea pig model of experimental dermatophytosis

The emergence of high-resistance strains to known antifungal drugs has highlighted the urgency of developing novel therapies for chronic dermatophytosis as a global health problem. An experimental dermatophytosis model in guinea pigs was developed to investigate the in vivo wound healing effects of...

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Published in:Diagnostic microbiology and infectious disease 2024-12, Vol.110 (4), p.116555, Article 116555
Main Authors: Safi-Samghabadi, Asal, Atyabi, Seyed-Mohammad, Shams-Ghahfarokhi, Masoomeh, Salehi, Zahra, Eslamifar, Ali, Jamzivar, Fatemehsadat, Razzaghi-Abyaneh, Mehdi
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Arthrodermataceae - drug effects
Arthrodermataceae - pathogenicity
Cold atmospheric plasma (CAP)
Disease Models, Animal
Experimental dermatophytosis
Guinea Pigs
Plasma Gases - pharmacology
Plasma Gases - therapeutic use
Skin - microbiology
Skin - pathology
Tinea - drug therapy
Tinea - microbiology
Treatment Outcome
Trichophyton - drug effects
Trichophyton rubrum
Virulence factors
Wound healing
Wound Healing - drug effects
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Summary:The emergence of high-resistance strains to known antifungal drugs has highlighted the urgency of developing novel therapies for chronic dermatophytosis as a global health problem. An experimental dermatophytosis model in guinea pigs was developed to investigate the in vivo wound healing effects of cold atmospheric plasma (CAP) on T. rubrum skin invasion. Guinea pigs were experimentally infected with T. rubrum and wound healing was evaluated at 1, 4, 8 and 12 days post infection in the CAP-treated, terbinafine-treated and non-treated controls. Our results showed that CAP strongly inhibited the fungal virulence in vitro in culture media and in vivo on the skin lesions of experimentally infected guinea pigs even more efficient than that of terbinafine, resulting in complete wound healing at 8 days post infection. These results indicate that CAP would be considered as a promising tool comparable to conventional chemical therapies, for the treatment of drug-resistant chronic dermatophytosis caused by T. rubrum. [Display omitted]
ISSN:0732-8893
1879-0070
1879-0070
DOI:10.1016/j.diagmicrobio.2024.116555