Biophysical characterization of RelA–p52 NF‐κB dimer—A link between the canonical and the non‐canonical NF‐κB pathway

The NF‐κB family consists of the key transcription factors of the NF‐κB signaling pathway, well known for its role in innate immune response, organogenesis, and a variety of cellular processes. The five NF‐κB subunits—RelA, RelB, c‐Rel, p50, and p52—are functional dimers, each of which share a conse...

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Published in:	Protein science 2024-11, Vol.33 (11), p.e5184-n/a
Main Authors:	Dhaka, Nitin, Misra, Subhranil, Sahoo, Sunirmala, Mukherjee, Sulakshana P.
Format:	Article
Language:	English
Subjects:	Activation analysis Calorimetry Combinatorial analysis Composition Differential scanning calorimetry dimer exchange dimer interface Dimerization Dimers Gene regulation Humans Immune response Innate immunity Magnetic resonance spectroscopy NF-kappa B p52 Subunit - chemistry NF-kappa B p52 Subunit - genetics NF-kappa B p52 Subunit - metabolism NF‐kappaB NF‐kB NMR NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular Organogenesis p50 p52 p65 Protein Multimerization RelA RelB protein Signal Transduction Transcription activation Transcription Factor RelA - chemistry Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription factors
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