Eggs, Dietary Choline, and Nonalcoholic Fatty Liver Disease in the Framingham Heart Study

Eggs are rich in bioactive compounds, including choline and carotenoids that may benefit cardiometabolic outcomes. However, little is known about their relationship with nonalcoholic fatty liver disease (NAFLD). We investigated the association between intakes of eggs and selected egg-rich nutrients...

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Bibliographic Details
Published in:The Journal of nutrition 2024-10
Main Authors: Yiannakou, Ioanna, Long, Michelle T, Jacques, Paul F, Beiser, Alexa, Pickering, Richard T, Moore, Lynn L
Format: Article
Language:English
Subjects:
dietary choline
eggs
liver fat
lutein
nonalcoholic fatty liver disease
zeaxanthin
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Summary:Eggs are rich in bioactive compounds, including choline and carotenoids that may benefit cardiometabolic outcomes. However, little is known about their relationship with nonalcoholic fatty liver disease (NAFLD). We investigated the association between intakes of eggs and selected egg-rich nutrients (choline, lutein, and zeaxanthin) and NAFLD risk and changes in liver fat over ∼6 y of follow-up in the Framingham Offspring and Third Generation cohorts. On 2 separate occasions (2002–2005 and 2008–2011), liver fat was assessed using a computed tomography scan to estimate the average liver fat attenuation relative to a control phantom to create the liver phantom ratio (LPR). In 2008–2011, cases of incident NAFLD were identified as an LPR ≤0.33 in the absence of heavy alcohol use, after excluding prevalent NAFLD (LPR ≤0.33) in 2002–2005. Food frequency questionnaires were used to estimate egg intakes (classified as
ISSN:0022-3166
1541-6100
1541-6100
DOI:10.1016/j.tjnut.2024.10.026