Abdominal Gynecologic Procedures in Pancreas Transplant Recipients

• Published in: Clinical transplantation 2024-10, Vol.38 (10), p.e70004-n/a
• Main Authors: Drury, Allison, Huber, Sarah, Loya, Elena, Powelson, John A., Lutz, Andrew, Kasper, Kelly, Rothenberg, Jeffrey M., Fridell, Jonathan A.
• Format: Article
• Language: English
• Subjects: Adult; Female; Follow-Up Studies; Genital Diseases, Female - surgery; Gynecologic Surgical Procedures - methods; gynecology; Humans; kidney transplant; Middle Aged; pancreas transplant; Pancreas Transplantation - adverse effects; Postoperative Complications; Prognosis; Retrospective Studies; Transplant Recipients - statistics & numerical data; Young Adult
• ISSN: 0902-0063; 1399-0012; 1399-0012
• DOI: 10.1111/ctr.70004

ABSTRACT Introduction With the growing population of pancreas transplant recipients followed long‐term, some female recipients are going to require surgical intervention for gynecologic symptoms and pathologies. Currently, there is a lack of literature describing how to approach this population and whether pelvic gynecologic procedures (GYN) can be performed safely given the proximity of the pancreatic (and possibly renal) allograft. In this single‐center retrospective analysis, all pancreas transplant recipients that subsequently underwent GYN were reviewed. Methods Subjects were identified by cross‐referencing all pancreas transplants performed between January 2003 and December 2022 for any subsequent GYN. Demographics at transplant and GYN, indications and procedure performed, operative time, presence and involvement of a transplant surgeon, complications length of stay, and readmissions were reviewed. Results Seventeen patients who underwent a total of 19 GYN after pancreas transplantation were identified. Operations performed included tubal ligation (n = 2), total abdominal hysterectomy with (n = 6) or without bilateral salpingectomy (n = 2), oophorectomy versus cyst drainage (n = 2), bilateral oophorectomy (n = 1), and unilateral (n = 4) versus bilateral (n = 2) salpingectomy. Four were performed through an open laparotomy and 15 were performed laparoscopically. In 11 cases, a transplant surgeon was involved intra‐operatively. Eight of the 17 patients developed post‐operative complications including post‐operative fevers, fluid overload, neutropenia, elevated creatinine (n = 2), nephrolithiasis, urinary tract infection, and incisional hernia. Five required readmission. Conclusion GYN can be performed safely following pancreas transplantation, but careful planning and the involvement of the transplant surgery team are advised.