In vitro skin permeation of flavonoid esters enzymatically derived from natural oils: release mechanism from gel emulsion, stability, and dermatological compatibility

Due to their broad spectrum of biological activities and attractive pharmacological properties, flavonoids are very promising molecules for application in skin care products. In this study, phloridzin and naringin medium- and long-chain fatty acid esters were enzymatically synthesized in reaction wi...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2024-12, Vol.29 (10), p.1121-1132
Main Authors: Milivojević, Ana, Ćorović, Marija, Petrov Ivanković, Anja, Simović, Milica, Banjanac, Katarina, Pjanović, Rada, Bezbradica, Dejan
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Emulsions
Esters - chemistry
Flavonoids - administration & dosage
Flavonoids - chemistry
Flavonoids - pharmacokinetics
Gels
Plant Oils - chemistry
Skin - metabolism
Skin Absorption - drug effects
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Summary:Due to their broad spectrum of biological activities and attractive pharmacological properties, flavonoids are very promising molecules for application in skin care products. In this study, phloridzin and naringin medium- and long-chain fatty acid esters were enzymatically synthesized in reaction with natural oils (coconut and linseed oil) and transdermal delivery of synthesized esters through artificial Strat-M membrane was investigated. Experimental results were succesfully fitted using Peppas and Sahlin model which includes the phase. Release kinetics of all examined flavonoid esters from gel emulsions through the membrane depended on both diffusion and polymer relaxation effect (0.5<  
ISSN:1083-7450
1097-9867
1097-9867
DOI:10.1080/10837450.2024.2424977