Management of high grade primary cerebellar tumours

Cerebellar high-grade gliomas (cHGG) are uncommon in adults, making up only about 1% of all high-grade gliomas. These tumours differ from supratentorial high-grade gliomas (sHGG) in terms of epidemiology, molecular traits, and the age of the patients. cHGG patients are typically younger and show a h...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2024-11, Vol.74 (11), p.2018-2020
Main Authors: Javed, Zanib, Sadiq, Raheema, Shamim, Muhammad Shahzad
Format: Article
Language:English
Subjects:
Care and treatment
Cerebellar Neoplasms - genetics
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - therapy
Cerebellum
Forecasts and trends
Glioma - genetics
Glioma - pathology
Glioma - therapy
Gliomas
Health aspects
Humans
Mutation
Neoplasm Grading
Patient outcomes
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Summary:Cerebellar high-grade gliomas (cHGG) are uncommon in adults, making up only about 1% of all high-grade gliomas. These tumours differ from supratentorial high-grade gliomas (sHGG) in terms of epidemiology, molecular traits, and the age of the patients. cHGG patients are typically younger and show a higher frequency of neurofibromatosis 1 (NF1) mutations, atypical RAS mutations, and H3K27M mutations. Standard treatment includes surgical resection followed by chemotherapy and radiation. Recent studies emphasize the genetic differences between cerebellar and supratentorial tumours, with new treatments targetting specific molecular abnormalities. Immunotherapy has shown limited effectiveness due to the unique tumour environment in cHGG, and further research is required to improve treatment strategies for these rare tumours.
ISSN:0030-9982
0030-9982
DOI:10.47391/JPMA.24-92