Circulating inflammatory proteins are elevated in type 1 and type 2 diabetes and associated to complications

The presence of low-grade inflammation has been reported in people with type 2 diabetes and related to the development of (macro)vascular complications. Whether systemic inflammation is present in type 1 diabetes and linked to long-term complications remains unknown. We used a targeted proteomics ap...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2024-11
Main Authors: van Heck, Julia I P, Ajie, Mandala, Joosten, Leo A B, Tack, Cees J, Stienstra, Rinke
Format: Article
Language:English
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Summary:The presence of low-grade inflammation has been reported in people with type 2 diabetes and related to the development of (macro)vascular complications. Whether systemic inflammation is present in type 1 diabetes and linked to long-term complications remains unknown. We used a targeted proteomics approach to compare inflammation in people with type 1 diabetes and type 2 diabetes with control subjects and linked these proteins to diabetes related characteristics and complications. We included 233 participants with type 1 diabetes, 387 participants with type 2 diabetes and 150 healthy controls. Plasma was collected and used to determine high sensitive C-reactive proteins (hs-CRP) and an additional 92 inflammatory proteins using the Olink proteomics platform. Compared to healthy controls, 41 circulating inflammatory proteins were higher in type 1 diabetes (FDR
ISSN:1462-8902
1463-1326
1463-1326
DOI:10.1111/dom.16066