Experimental Study of Products Based on Biocompatible Polymer Material from Methacrylic Oligomers as a Potential Barrier for Preventing Adhesions in Cardiac Surgery

• Published in: Bulletin of experimental biology and medicine 2024-11, Vol.178 (1), p.163-168
• Main Authors: Egunov, O. A., Afanasiev, S. A., Kondratieva, D. S., Muslimova, E. F., Stepanov, I. V., Grishin, A. S., Mikheeva, E. R., Boshchenko, A. A.
• Format: Article
• Language: English
• Subjects: Abdominal surgery; Adhesion; Animals; Biocompatibility; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biomedical and Life Sciences; Biomedicine; Cardiac Surgical Procedures; Cardiology; Cell Biology; Experiments; Fibroblasts; Fibroblasts - drug effects; Fibrosis; Heart surgery; Humans; Internal Medicine; Laboratory Medicine; Male; Materials Testing; Medical research; Methacrylates - chemistry; Methacrylates - pharmacology; Morphology; Muscles; Nylons - chemistry; Nylons - pharmacology; Oligomers; Pathology; Polymers; Polymers - chemistry; Polymers - pharmacology; Rats; Rats, Wistar; Surgical Mesh; Testing laboratories; Tissue Adhesions - pathology; Tissue Adhesions - prevention & control
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06300-y

The effectiveness and safety of two types of samples based on a biocompatible polymer material made of methacrylic oligomers (Reperen) as a potential antiadhesion pericardial barrier were evaluated in in vitro and in vivo experiments. Two kinds of samples, reinforced with a polyamide mesh and without reinforcement, were used. In in vitro experiments, no adhesion and aggregation of human fibroblasts to the test samples were detected. In in vivo experiments, the samples implanted to rats into the thigh muscles were easily separated from the surrounding tissues 1, 2, and 3 weeks after implantation, being weakly fixed only in the area of the edges. Histological examination at week 2 after implantation revealed no differences between the experimental and control groups. At week 1 and 3, fibrosis and inflammation were more pronounced in animals of the control group (with simulated implantation). The properties demonstrated by both samples of Reperen barriers (with and without polyamide mesh reinforcement) in vivo and in vitro allow considering them as a potential antiadhesion pericardial barrier for clinical use.