Elevated blood pressure variability is associated with an increased risk of negative health outcomes in adults aged 65 and above-a systematic review and meta-analysis

The clinical relevance of blood pressure variability (BPV) is still unknown, despite increasing evidence associating BPV to negative health outcomes (NHOs). There is currently no gold standard to define high BPV and normal reference values for BPV are lacking. The primary aim was to examine whether...

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Bibliographic Details
Published in:Age and ageing 2024-11, Vol.53 (12)
Main Authors: Saren, Jordy, Debain, Aziz, Loosveldt, Fien, Petrovic, Mirko, Bautmans, Ivan
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Blood Pressure
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Female
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Male
Prognosis
Risk Assessment
Risk Factors
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Summary:The clinical relevance of blood pressure variability (BPV) is still unknown, despite increasing evidence associating BPV to negative health outcomes (NHOs). There is currently no gold standard to define high BPV and normal reference values for BPV are lacking. The primary aim was to examine whether high BPV can predict NHO in adults aged ≥65. The predictive value of BPV was compared to mean BP (mBP) when both parameters were available. PubMed and Web of Science were systematically screened; 49 articles (12 retrospective, 18 prospective and 19 cross-sectional studies) were included and evaluated for methodological quality. Meta-analyses were conducted to examine the association of BPV (and mBP when available) with NHO. Systolic BPV and systolic mBP seem to indicate at least comparable odds for cardiovascular disease (BPV: odds ratio (OR) = 1.33 (95% CI: 1.19-1.48, P 
ISSN:1468-2834
1468-2834
DOI:10.1093/ageing/afae262