Histopathological evidence of cellular alterations in the dentate gyrus is associated with aberrant RB1CC1-ATG16L1 expression in the hippocampus among older adults with chronic schizophrenia: A pilot post-mortem study

Recent evidence brings autophagy, and specifically the RB1CC1 gene into sharp focus as aetiologically relevant to Schizophrenia. Our understanding of whether and how these genetic signatures translate to cellular functions remains limited. Post-mortem study of 10 individuals with Schizophrenia and 1...

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Bibliographic Details
Published in:Schizophrenia research 2025-01, Vol.275, p.14-24
Main Authors: Lappas, Andreas S., Ioannou, Maria, Christodoulou, Nikos G.
Format: Article
Language:English
Subjects:
ATG16L1
Autophagy
Hippocampus
Pathology
RB1CC1
Schizophrenia
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Summary:Recent evidence brings autophagy, and specifically the RB1CC1 gene into sharp focus as aetiologically relevant to Schizophrenia. Our understanding of whether and how these genetic signatures translate to cellular functions remains limited. Post-mortem study of 10 individuals with Schizophrenia and 18 individuals without any neurological/psychiatric disorder, matched for age, sex, post-mortem-interval, pH and BRAAK score. Formalin-fixed, paraffin-embedded, 6 μm sections cut through segments of the anterior, middle and posterior left or right hippocampus were examined for histopathological differences and immunohistochemical expression of RB1CC1 and ATG16L1 proteins. Dentate gyrus (DG) granule cells area (p = 0.005) and circularity (p = 0.012) were significantly lower among Schizophrenia vs. controls. Antipsychotics were associated with lower circularity (p = 0.007). RB1CC1 and ATG16L1 immunoexpression were positively correlated (p 
ISSN:0920-9964
1573-2509
1573-2509
DOI:10.1016/j.schres.2024.11.009