Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection

Candida albicans is the most common human fungal pathogen, causing diseases ranging from local to life-threating systemic infections. Tyrosine kinase 2 (TYK2), a crucial mediator in several cytokine signaling pathways, has been associated with protective functions in various microbial infections. Ho...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2024-12, Vol.15 (1), p.10493-16, Article 10493
Main Authors: Miranda, Sara, Lassnig, Caroline, Schmidhofer, Kristina, Kjartansdottir, Hrönn, Vogl, Claus, Tangermann, Simone, Tsymala, Irina, Babl, Verena, Müller, Mathias, Kuchler, Karl, Strobl, Birgit
Format: Article
Language:English
Subjects:
13
13/1
13/31
13/51
38
38/77
38/88
38/90
38/91
631/250/2499
631/250/254
64
64/110
64/60
692/699/255/1672
Animals
Antifungal agents
Candida albicans
Candida albicans - immunology
Candidiasis
Candidiasis - genetics
Candidiasis - immunology
Candidiasis - microbiology
Candidiasis, Cutaneous - genetics
Candidiasis, Cutaneous - immunology
Candidiasis, Cutaneous - metabolism
Candidiasis, Cutaneous - microbiology
Disseminated infection
Enzymatic activity
Female
Fungi
Fungicides
Humanities and Social Sciences
Immune response
Infections
Interferon
Interferon-gamma - immunology
Interferon-gamma - metabolism
Kinases
Leukocytes (neutrophilic)
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microorganisms
multidisciplinary
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Pathogens
Science
Science (multidisciplinary)
Signal Transduction
Skin - immunology
Skin - microbiology
Skin diseases
Skin resistance
Transcriptomics
TYK2 Kinase - genetics
TYK2 Kinase - metabolism
Tyk2 protein
Tyrosine
Wound healing
Wound Healing - genetics
Wound Healing - immunology
Wound infection
γ-Interferon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!