Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive from a transient, common pancreatic progenitor. Here, we report derivation of 18 human f...

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Published in:	Cell 2024-12, Vol.187 (26), p.7394-7413.e22
Main Authors:	Andersson-Rolf, Amanda, Groot, Kelvin, Korving, Jeroen, Begthel, Harry, Hanegraaf, Maaike A.J., VanInsberghe, Michael, Salmén, Fredrik, van den Brink, Stieneke, Lopez-Iglesias, Carmen, Peters, Peter J., Krueger, Daniel, Beumer, Joep, Geurts, Maarten H., Alemany, Anna, Gehart, Helmuth, Carlotti, Françoise, de Koning, Eelco J.P., Chuva de Sousa Lopes, Susana M., van Oudenaarden, Alexander, van Es, Johan H., Clevers, Hans
Format:	Article
Language:	English
Subjects:	acinar cells Acinar Cells - cytology Acinar Cells - metabolism adults Animals Cell Differentiation Cell Lineage Cell Proliferation development digestive tract endocrine cells epithelium fetal pancreas Fetal Stem Cells - cytology Fetal Stem Cells - metabolism Fetus - cytology human organoids Humans Islets of Langerhans - cytology Islets of Langerhans - embryology Islets of Langerhans - metabolism LGR5 Mice organoids Organoids - cytology Organoids - metabolism pancreas Pancreas - cytology Pancreas - embryology Receptors, G-Protein-Coupled - metabolism RNA Single-Cell Analysis stem cell stem cells tripotent stem cell
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