Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from Routine Physical Examination Report

• Published in: Biological trace element research 2024-12
• Main Authors: Pan, Rou-Jun, Luo, Zhi, You, Yu-Shun, Wang, Jun-Dong, Chen, Ya-Qi, Zhou, Rong-Rong, Chen, Shu-Zi-Qi, Wang, Lin-Min, Zhao, Jun-Xiang, Su, Hua-Qin, Wang, Cai-Li, Zhang, Li-Fen, Peng, Feng-Lian, Meneses, Jezza Joi, Wang, Xiang-Hu, He, Lian-Ping, Wang, Ting
• Format: Article
• Language: English
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-024-04459-z

Dyslipidemia is related to the occurrence and development of many diseases and is a common problem among the general population. A significant link has been identified between dyslipidemia and ferroptosis. Lipid profile parameters are important indicators of dyslipidemia. Iron is the main cause of ferroptosis. However, the relationship between blood lipid parameters and whole blood iron levels has remained unclear. Based on a community population, the study aimed to explore the relationship between whole blood iron levels and blood lipids in Taizhou, China. The blood samples were collected from 1917 community residents, and levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and whole blood iron were measured. Pearson correlation was used to analyze the correlation between whole blood iron levels and lipids profile parameters. The results of the study showed that for both men and women, whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P