Association Between Melanoma Metastasis and Metabolic Syndrome: A Cross-Sectional Study in a Chinese Population

Metabolic syndrome (MetS) remains a significant global public health concern. However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanoma patients who had not undergo systemic therapy. Binary logi...

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Published in:Pigment cell and melanoma research 2025-01, Vol.38 (1), p.e13203
Main Authors: Sha, Shanshan, Sun, Shuomin, Dong, Liyun, Wei, Haoran, Chen, Weiyu, Dong, Enzhu, Li, Lu, Lan, Jiajia, Li, Jun, Yang, Liu, Chen, Yong, Tao, Juan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asian People
China - epidemiology
Cholesterol, HDL - blood
Cross-Sectional Studies
East Asian People
Female
Humans
Male
Melanoma - pathology
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - pathology
Middle Aged
Neoplasm Metastasis
Skin Neoplasms - pathology
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container_title Pigment cell and melanoma research
container_volume 38
creator Sha, Shanshan
Sun, Shuomin
Dong, Liyun
Wei, Haoran
Chen, Weiyu
Dong, Enzhu
Li, Lu
Lan, Jiajia
Li, Jun
Yang, Liu
Chen, Yong
Tao, Juan
description Metabolic syndrome (MetS) remains a significant global public health concern. However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanoma patients who had not undergo systemic therapy. Binary logistic regression, adjusted for sex and age, was employed to evaluate the connection between MetS and its components and melanoma metastasis. Of the 258 melanoma patients, 92 met the MetS criteria upon diagnosis. No direct association between MetS and melanoma metastasis was identified. However, specific components of MetS, namely low HDL-cholesterol levels (OR = 2.85, 95% CI:1.50-5.41, p 
doi_str_mv 10.1111/pcmr.13203
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However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanoma patients who had not undergo systemic therapy. Binary logistic regression, adjusted for sex and age, was employed to evaluate the connection between MetS and its components and melanoma metastasis. Of the 258 melanoma patients, 92 met the MetS criteria upon diagnosis. No direct association between MetS and melanoma metastasis was identified. However, specific components of MetS, namely low HDL-cholesterol levels (OR = 2.85, 95% CI:1.50-5.41, p &lt; 0.05) and dysglycaemia (OR = 4.23, 95% CI:1.80-8.96, p &lt; 0.05), were associated with melanoma metastasis. In subgroup analysis, hypertriglyceridemia correlated with melanoma metastasis in non-elderly patients (&lt; 65 years) (OR = 2.69, 95% CI: 1.14-6.33, p &lt; 0.05). Central obesity and hypertension showed no association. A dose-response analysis further indicated that melanoma metastasis risk escalated with increasing fasting blood glucose and blood triglyceride concentrations, and with decreasing blood HDL concentration. Our results suggest that monitoring and managing individual components of the MetS, particularly HDL-cholesterol levels, fasting glucose and triglyceride levels, may have potential prognostic benefits for melanoma in the Chinese population.</description><identifier>ISSN: 1755-148X</identifier><identifier>EISSN: 1755-148X</identifier><identifier>DOI: 10.1111/pcmr.13203</identifier><identifier>PMID: 39656511</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asian People ; China - epidemiology ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; East Asian People ; Female ; Humans ; Male ; Melanoma - pathology ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - pathology ; Middle Aged ; Neoplasm Metastasis ; Skin Neoplasms - pathology</subject><ispartof>Pigment cell and melanoma research, 2025-01, Vol.38 (1), p.e13203</ispartof><rights>2024 John Wiley &amp; Sons A/S. 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A dose-response analysis further indicated that melanoma metastasis risk escalated with increasing fasting blood glucose and blood triglyceride concentrations, and with decreasing blood HDL concentration. 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However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanoma patients who had not undergo systemic therapy. Binary logistic regression, adjusted for sex and age, was employed to evaluate the connection between MetS and its components and melanoma metastasis. Of the 258 melanoma patients, 92 met the MetS criteria upon diagnosis. No direct association between MetS and melanoma metastasis was identified. However, specific components of MetS, namely low HDL-cholesterol levels (OR = 2.85, 95% CI:1.50-5.41, p &lt; 0.05) and dysglycaemia (OR = 4.23, 95% CI:1.80-8.96, p &lt; 0.05), were associated with melanoma metastasis. In subgroup analysis, hypertriglyceridemia correlated with melanoma metastasis in non-elderly patients (&lt; 65 years) (OR = 2.69, 95% CI: 1.14-6.33, p &lt; 0.05). Central obesity and hypertension showed no association. A dose-response analysis further indicated that melanoma metastasis risk escalated with increasing fasting blood glucose and blood triglyceride concentrations, and with decreasing blood HDL concentration. Our results suggest that monitoring and managing individual components of the MetS, particularly HDL-cholesterol levels, fasting glucose and triglyceride levels, may have potential prognostic benefits for melanoma in the Chinese population.</abstract><cop>England</cop><pmid>39656511</pmid><doi>10.1111/pcmr.13203</doi></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Asian People
China - epidemiology
Cholesterol, HDL - blood
Cross-Sectional Studies
East Asian People
Female
Humans
Male
Melanoma - pathology
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - pathology
Middle Aged
Neoplasm Metastasis
Skin Neoplasms - pathology
title Association Between Melanoma Metastasis and Metabolic Syndrome: A Cross-Sectional Study in a Chinese Population
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