Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults

• Published in: The American journal of cardiology 2024-12
• Main Authors: Bcharah, George, Firth, Christine E., Abdou, Merna M., Ravi, Srekar N., Ibrahim, Ramzi, Pathangey, Girish, Kumar, Sant J., Abdelnabi, Mahmoud H., Wang, Yuxiang, Osundiji, Mayoma A., Shamoun, Fadi E.
• Format: Article
• Language: English
• Subjects: aortopathies; large-vessel aneurysms; medium-vessel aneurysms; Non-syndromic arteriopathies; sex differences
• ISSN: 0002-9149; 1879-1913; 1879-1913
• DOI: 10.1016/j.amjcard.2024.12.009

•Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites.•Both sexes have peak arterial dissection rates in the 36-45 age range. Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are non-syndromic. Manifestations of these non-syndromic arteriopathies across sexes and age groups have not been discussed extensively in the literature, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes. Patients ≤ 60-years-old were included and grouped by sex and into five age groups (18-60). The odds and prevalence of various arteriopathies and complications (i.e. revascularization, stroke, dissection, and death) were compared. Overall, 909 patients ≤ 60 years-old were included with 68.0% females (mean age=47.49). Females were more likely to have carotid/cerebral aneurysms (55.2% vs 31.6%, p