Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults

•Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites....

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2024-12
Main Authors: Bcharah, George, Firth, Christine E., Abdou, Merna M., Ravi, Srekar N., Ibrahim, Ramzi, Pathangey, Girish, Kumar, Sant J., Abdelnabi, Mahmoud H., Wang, Yuxiang, Osundiji, Mayoma A., Shamoun, Fadi E.
Format: Article
Language:English
Subjects:
aortopathies
large-vessel aneurysms
medium-vessel aneurysms
Non-syndromic arteriopathies
sex differences
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue
container_start_page
container_title The American journal of cardiology
container_volume
creator Bcharah, George
Firth, Christine E.
Abdou, Merna M.
Ravi, Srekar N.
Ibrahim, Ramzi
Pathangey, Girish
Kumar, Sant J.
Abdelnabi, Mahmoud H.
Wang, Yuxiang
Osundiji, Mayoma A.
Shamoun, Fadi E.
description •Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites.•Both sexes have peak arterial dissection rates in the 36-45 age range. Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are non-syndromic. Manifestations of these non-syndromic arteriopathies across sexes and age groups have not been discussed extensively in the literature, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes. Patients ≤ 60-years-old were included and grouped by sex and into five age groups (18-60). The odds and prevalence of various arteriopathies and complications (i.e. revascularization, stroke, dissection, and death) were compared. Overall, 909 patients ≤ 60 years-old were included with 68.0% females (mean age=47.49). Females were more likely to have carotid/cerebral aneurysms (55.2% vs 31.6%, p
doi_str_mv 10.1016/j.amjcard.2024.12.009
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3146662921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000291492400852X</els_id><sourcerecordid>3146662921</sourcerecordid><originalsourceid>FETCH-LOGICAL-e1124-e836c995bf8b6be8fa23bbc8db7d60646111e0523313aae9605cda9937ae51223</originalsourceid><addsrcrecordid>eNo10D1PwzAQgGELgWgp_ARQRpYEn5248YRC-ZQqGEoHJsuxL8VVkxQ7QfTfk4oyWSe_Op0eQi6BJkBB3KwTXa-N9jZhlKUJsIRSeUTGkE9lDBL4MRlTSlksIZUjchbCehgBMnFKRlwKMc0gHZPlAn_iSDc2KlYY3-mANrp3VYUeG4Mhck302jbxYtdY39bORIXv0Lt2q7tPN_wXddusQhd9tH2zQh8Vtt904ZycVHoT8OLwTsjy8eF99hzP355eZsU8RgCWxphzYaTMyiovRYl5pRkvS5PbcmoFFakAAKQZ4xy41igFzYzVUvKpxgwY4xNy_bd369uvHkOnahcMbja6wbYPikMqhGCSwZBeHdK-rNGqrXe19jv1TzEEt38BDgd_O_QqGLdHsM6j6ZRtnQKq9vhqrQ74ao-vgKkBn_8CeFN3Yw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3146662921</pqid></control><display><type>article</type><title>Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults</title><source>ScienceDirect Freedom Collection</source><creator>Bcharah, George ; Firth, Christine E. ; Abdou, Merna M. ; Ravi, Srekar N. ; Ibrahim, Ramzi ; Pathangey, Girish ; Kumar, Sant J. ; Abdelnabi, Mahmoud H. ; Wang, Yuxiang ; Osundiji, Mayoma A. ; Shamoun, Fadi E.</creator><creatorcontrib>Bcharah, George ; Firth, Christine E. ; Abdou, Merna M. ; Ravi, Srekar N. ; Ibrahim, Ramzi ; Pathangey, Girish ; Kumar, Sant J. ; Abdelnabi, Mahmoud H. ; Wang, Yuxiang ; Osundiji, Mayoma A. ; Shamoun, Fadi E.</creatorcontrib><description>•Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites.•Both sexes have peak arterial dissection rates in the 36-45 age range. Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are non-syndromic. Manifestations of these non-syndromic arteriopathies across sexes and age groups have not been discussed extensively in the literature, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes. Patients ≤ 60-years-old were included and grouped by sex and into five age groups (18-60). The odds and prevalence of various arteriopathies and complications (i.e. revascularization, stroke, dissection, and death) were compared. Overall, 909 patients ≤ 60 years-old were included with 68.0% females (mean age=47.49). Females were more likely to have carotid/cerebral aneurysms (55.2% vs 31.6%, p&lt;0.0001), and males were more likely to have thoracic (50.9% vs 21.8%, p&lt;0.0001) and abdominal aortic aneurysms (7.22% vs 2.59%, p&lt;0.01). Males with splanchnic and carotid/cerebral aneurysms were more likely to dissect (58.14% vs 21.49% and 45.65% vs 30.79% p&lt;0.05, respectively). Females were more likely to have multi-site aneurysms (16.34% vs 12.03%, p&lt;0.05), with the most common being concurrent carotid/cerebral and splanchnic aneurysms. Both sexes showed peak dissection rates at ages 36-45, although males experienced more complications in older age groups (56-60) and females in younger ones (46-55). In conclusion, males are more susceptible to large vessel aneurysms and complications later in life, whereas females more frequently experience medium vessel aneurysms, complications earlier in life, and co-occurring multi-site aneurysms. Potential un-identified genetic factors could be influencing these patterns.</description><identifier>ISSN: 0002-9149</identifier><identifier>ISSN: 1879-1913</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2024.12.009</identifier><identifier>PMID: 39667514</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>aortopathies ; large-vessel aneurysms ; medium-vessel aneurysms ; Non-syndromic arteriopathies ; sex differences</subject><ispartof>The American journal of cardiology, 2024-12</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39667514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bcharah, George</creatorcontrib><creatorcontrib>Firth, Christine E.</creatorcontrib><creatorcontrib>Abdou, Merna M.</creatorcontrib><creatorcontrib>Ravi, Srekar N.</creatorcontrib><creatorcontrib>Ibrahim, Ramzi</creatorcontrib><creatorcontrib>Pathangey, Girish</creatorcontrib><creatorcontrib>Kumar, Sant J.</creatorcontrib><creatorcontrib>Abdelnabi, Mahmoud H.</creatorcontrib><creatorcontrib>Wang, Yuxiang</creatorcontrib><creatorcontrib>Osundiji, Mayoma A.</creatorcontrib><creatorcontrib>Shamoun, Fadi E.</creatorcontrib><title>Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>•Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites.•Both sexes have peak arterial dissection rates in the 36-45 age range. Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are non-syndromic. Manifestations of these non-syndromic arteriopathies across sexes and age groups have not been discussed extensively in the literature, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes. Patients ≤ 60-years-old were included and grouped by sex and into five age groups (18-60). The odds and prevalence of various arteriopathies and complications (i.e. revascularization, stroke, dissection, and death) were compared. Overall, 909 patients ≤ 60 years-old were included with 68.0% females (mean age=47.49). Females were more likely to have carotid/cerebral aneurysms (55.2% vs 31.6%, p&lt;0.0001), and males were more likely to have thoracic (50.9% vs 21.8%, p&lt;0.0001) and abdominal aortic aneurysms (7.22% vs 2.59%, p&lt;0.01). Males with splanchnic and carotid/cerebral aneurysms were more likely to dissect (58.14% vs 21.49% and 45.65% vs 30.79% p&lt;0.05, respectively). Females were more likely to have multi-site aneurysms (16.34% vs 12.03%, p&lt;0.05), with the most common being concurrent carotid/cerebral and splanchnic aneurysms. Both sexes showed peak dissection rates at ages 36-45, although males experienced more complications in older age groups (56-60) and females in younger ones (46-55). In conclusion, males are more susceptible to large vessel aneurysms and complications later in life, whereas females more frequently experience medium vessel aneurysms, complications earlier in life, and co-occurring multi-site aneurysms. Potential un-identified genetic factors could be influencing these patterns.</description><subject>aortopathies</subject><subject>large-vessel aneurysms</subject><subject>medium-vessel aneurysms</subject><subject>Non-syndromic arteriopathies</subject><subject>sex differences</subject><issn>0002-9149</issn><issn>1879-1913</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo10D1PwzAQgGELgWgp_ARQRpYEn5248YRC-ZQqGEoHJsuxL8VVkxQ7QfTfk4oyWSe_Op0eQi6BJkBB3KwTXa-N9jZhlKUJsIRSeUTGkE9lDBL4MRlTSlksIZUjchbCehgBMnFKRlwKMc0gHZPlAn_iSDc2KlYY3-mANrp3VYUeG4Mhck302jbxYtdY39bORIXv0Lt2q7tPN_wXddusQhd9tH2zQh8Vtt904ZycVHoT8OLwTsjy8eF99hzP355eZsU8RgCWxphzYaTMyiovRYl5pRkvS5PbcmoFFakAAKQZ4xy41igFzYzVUvKpxgwY4xNy_bd369uvHkOnahcMbja6wbYPikMqhGCSwZBeHdK-rNGqrXe19jv1TzEEt38BDgd_O_QqGLdHsM6j6ZRtnQKq9vhqrQ74ao-vgKkBn_8CeFN3Yw</recordid><startdate>20241210</startdate><enddate>20241210</enddate><creator>Bcharah, George</creator><creator>Firth, Christine E.</creator><creator>Abdou, Merna M.</creator><creator>Ravi, Srekar N.</creator><creator>Ibrahim, Ramzi</creator><creator>Pathangey, Girish</creator><creator>Kumar, Sant J.</creator><creator>Abdelnabi, Mahmoud H.</creator><creator>Wang, Yuxiang</creator><creator>Osundiji, Mayoma A.</creator><creator>Shamoun, Fadi E.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20241210</creationdate><title>Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults</title><author>Bcharah, George ; Firth, Christine E. ; Abdou, Merna M. ; Ravi, Srekar N. ; Ibrahim, Ramzi ; Pathangey, Girish ; Kumar, Sant J. ; Abdelnabi, Mahmoud H. ; Wang, Yuxiang ; Osundiji, Mayoma A. ; Shamoun, Fadi E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1124-e836c995bf8b6be8fa23bbc8db7d60646111e0523313aae9605cda9937ae51223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>aortopathies</topic><topic>large-vessel aneurysms</topic><topic>medium-vessel aneurysms</topic><topic>Non-syndromic arteriopathies</topic><topic>sex differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bcharah, George</creatorcontrib><creatorcontrib>Firth, Christine E.</creatorcontrib><creatorcontrib>Abdou, Merna M.</creatorcontrib><creatorcontrib>Ravi, Srekar N.</creatorcontrib><creatorcontrib>Ibrahim, Ramzi</creatorcontrib><creatorcontrib>Pathangey, Girish</creatorcontrib><creatorcontrib>Kumar, Sant J.</creatorcontrib><creatorcontrib>Abdelnabi, Mahmoud H.</creatorcontrib><creatorcontrib>Wang, Yuxiang</creatorcontrib><creatorcontrib>Osundiji, Mayoma A.</creatorcontrib><creatorcontrib>Shamoun, Fadi E.</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bcharah, George</au><au>Firth, Christine E.</au><au>Abdou, Merna M.</au><au>Ravi, Srekar N.</au><au>Ibrahim, Ramzi</au><au>Pathangey, Girish</au><au>Kumar, Sant J.</au><au>Abdelnabi, Mahmoud H.</au><au>Wang, Yuxiang</au><au>Osundiji, Mayoma A.</au><au>Shamoun, Fadi E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2024-12-10</date><risdate>2024</risdate><issn>0002-9149</issn><issn>1879-1913</issn><eissn>1879-1913</eissn><abstract>•Males are more likely to have non-syndromic large vessel aneurysms.•Females are more likely to have non-syndromic medium vessel aneurysms.•Males have worse complications when they experience non-syndromic medium vessel aneurysms.•Females are more likely to have aneurysms at multiple arterial sites.•Both sexes have peak arterial dissection rates in the 36-45 age range. Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are non-syndromic. Manifestations of these non-syndromic arteriopathies across sexes and age groups have not been discussed extensively in the literature, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes. Patients ≤ 60-years-old were included and grouped by sex and into five age groups (18-60). The odds and prevalence of various arteriopathies and complications (i.e. revascularization, stroke, dissection, and death) were compared. Overall, 909 patients ≤ 60 years-old were included with 68.0% females (mean age=47.49). Females were more likely to have carotid/cerebral aneurysms (55.2% vs 31.6%, p&lt;0.0001), and males were more likely to have thoracic (50.9% vs 21.8%, p&lt;0.0001) and abdominal aortic aneurysms (7.22% vs 2.59%, p&lt;0.01). Males with splanchnic and carotid/cerebral aneurysms were more likely to dissect (58.14% vs 21.49% and 45.65% vs 30.79% p&lt;0.05, respectively). Females were more likely to have multi-site aneurysms (16.34% vs 12.03%, p&lt;0.05), with the most common being concurrent carotid/cerebral and splanchnic aneurysms. Both sexes showed peak dissection rates at ages 36-45, although males experienced more complications in older age groups (56-60) and females in younger ones (46-55). In conclusion, males are more susceptible to large vessel aneurysms and complications later in life, whereas females more frequently experience medium vessel aneurysms, complications earlier in life, and co-occurring multi-site aneurysms. Potential un-identified genetic factors could be influencing these patterns.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39667514</pmid><doi>10.1016/j.amjcard.2024.12.009</doi></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2024-12
issn 0002-9149
1879-1913
1879-1913
language eng
recordid cdi_proquest_miscellaneous_3146662921
source ScienceDirect Freedom Collection
subjects aortopathies
large-vessel aneurysms
medium-vessel aneurysms
Non-syndromic arteriopathies
sex differences
title Sex- and Age-Based Differences in Non-Syndromic Arteriopathies Amongst Younger Adults
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T03%3A45%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex-%20and%20Age-Based%20Differences%20in%20Non-Syndromic%20Arteriopathies%20Amongst%20Younger%20Adults&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Bcharah,%20George&rft.date=2024-12-10&rft.issn=0002-9149&rft.eissn=1879-1913&rft_id=info:doi/10.1016/j.amjcard.2024.12.009&rft_dat=%3Cproquest_pubme%3E3146662921%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-e1124-e836c995bf8b6be8fa23bbc8db7d60646111e0523313aae9605cda9937ae51223%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3146662921&rft_id=info:pmid/39667514&rfr_iscdi=true