In vitro ultrastructure and biodegradation of activated plasma albumin gel derived from human samples: A prospective observational study

• Published in: Clinical advances in periodontics 2024-12
• Main Authors: Houshmand, Behzad, Ardakani, Mohammadreza Talebi, Armandei, Farshad, Moscowchi, Anahita, Nazari, Ahmad, Ai, Jafar, Kermani, Mehdi Ekhlasmand, Sabri, Hamoun
• Format: Article
• Language: English
• ISSN: 2163-0097; 2163-0097
• DOI: 10.1002/cap.10330

In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative. This study investigates the ultrastructure and biodegradability of plasma albumin-activated gel, a potential game-changer in the field. Blood samples were collected from the participants and centrifuged to obtain the concentrated growth factor. The poor platelet plasma syringe was placed inside the activated plasma albumin gel device. The ultrastructure of the membrane was examined using a scanning electron microscope (SEM). The weight difference was measured over 21 days to investigate the biodegradability of the samples. Twenty-two samples were prepared from six individuals (three males and three females). Based on SEM images, activated albumin gel after 21 days in Hank's solution exhibited a significant decrease in density and evident signs of surface degradation. The weight was significantly reduced after 21 days (p