Wogonin induces apoptosis in macrophages by exhibiting cytotoxic and genotoxic effects

Macrophages play an important role in defending the body against invading pathogens. In the face of pathogens, macrophages become activated and release toxic materials that disrupt the pathogens. Macrophage overactivation can lead to severe illness and inflammation. Wogonin has several therapeutic e...

Full description

Saved in:
Bibliographic Details
Published in:Environmental toxicology 2024-05, Vol.39 (5), p.2927-2936
Main Authors: Tsai, Ping‐Kun, Chiang, Chen‐Yu, Wang, Tzu‐Ching, Yeh, Kun‐Lin, Chen, Wen‐Ying, Chen, Chun‐Jung, Tseng, Ching‐Chi, Deng, Lie‐Hua, Tzen, Jason Tze Cheng, Lu, Yin‐Che, Kuan, Yu‐Hsiang
Format: Article
Language:English
Subjects:
Anticancer properties
antioxidants
Apoptosis
Caspase
caspase-3
caspase-8
caspase-9
caspases
Cytotoxicity
death domain receptors
disease severity
ecotoxicology
Genotoxicity
Inflammation
macrophage
Macrophages
mitochondria
mutagens
Necrosis
Neuroprotection
Pathogens
therapeutics
Toxic materials
wogonin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Macrophages play an important role in defending the body against invading pathogens. In the face of pathogens, macrophages become activated and release toxic materials that disrupt the pathogens. Macrophage overactivation can lead to severe illness and inflammation. Wogonin has several therapeutic effects, including anti‐inflammatory, anticancer, antioxidant, and neuroprotective effects. No studies have investigated the cytotoxic effects of wogonin at concentrations of more than 0.1 mM in RAW264.7 cells. In this study, RAW 264.7 cells were treated with wogonin, which, at concentrations of more than 0.1 mM, had cytotoxic and genotoxic effects in the RAW264.7 cells, leading to apoptosis and necrosis. Further, wogonin at concentrations of more than 0.1 mM induced caspase‐3, caspase‐8, and caspase‐9 activation and mitochondrial dysfunction and death receptor expression. These results suggest that wogonin induces apoptosis through upstream intrinsic and extrinsic pathways by exhibiting cytotoxic and genotoxic effects.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.24150