Distance between tumor and bronchial resection margin is an independent predictor of recurrence-free survival and overall survival in primary endobronchial neoplasm

• Published in: Journal of cancer research and clinical oncology 2023-10, Vol.149 (13), p.11171-11180
• Main Authors: Xiao, Zengtuan, Zhang, Mengzhe, Liu, Zuo, Wang, Xiaofei, Liu, Zhe, Zhang, Zhenfa
• Format: Article
• Language: English
• Subjects: adjuvants; Cancer Research; formalin; hazard ratio; Hematology; Internal Medicine; Lung cancer; lung neoplasms; Medicine; Medicine & Public Health; Neoplasia; Oncology; resection; Surgery; Survival; Tumors
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/s00432-023-04917-6

Background The distance between tumor and bronchial resection margin (DBTM) had no clear standard in lung cancer surgery. We aimed to select the optimal cut-off value to provide a standard for surgery of the patients with primary endobronchial neoplasm. Methods We retrospectively analyzed patients with primary endobronchial neoplasm who underwent surgical resection between 2005 and 2012. The receiver operating characteristic curves and the Youden index were used to calculate the optimal cut-off value of the DBTM. Propensity score matching was applied to reduce selection bias. Survival was assessed with Kaplan–Meier analysis, log-rank test and Cox proportional hazards model. Results A total of 1048 patients comprised in the study cohort and 1.7 cm was determined the optimal cut-off value, including 531 grouped in DBTM ≤ 1.7 cm and 517 grouped in DBTM > 1.7 cm. Before propensity score matching, the 5-year recurrence-free survival was 38.7% in DBTM ≤ 1.7 cm group and 67.1% in DBTM > 1.7 cm (hazard ratio 0.48, P