Palladium-Catalyzed Domino Conversion of Aryl–Thianthreniums with Anhydrides: Rapidly Building Highly Functionalized Fluorenones

As a class of rising electrophilic coupling reagents, aryl–thianthreniums (aryl-TTs) have been gaining immense attention. Herein, a novel palladium-catalyzed domino annulation of aryl-TTs with anhydrides is proposed to rapidly assemble a collection of highly functionalized fluorenones. This finding...

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Bibliographic Details
Published in:Organic letters 2024-04, Vol.26 (16), p.3332-3337
Main Authors: Nan, Jiang, Xiao, Haiyan, Ma, Yangmin, Fan, Liangxin, Wang, Jing
Format: Article
Language:English
Subjects:
anhydrides
couplings
Lewis acids
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Summary:As a class of rising electrophilic coupling reagents, aryl–thianthreniums (aryl-TTs) have been gaining immense attention. Herein, a novel palladium-catalyzed domino annulation of aryl-TTs with anhydrides is proposed to rapidly assemble a collection of highly functionalized fluorenones. This finding presents an innovative reaction pattern of aryl-TTs wherein the domino annulation version is first involved. Heavily compared with the existing conversions with aryl-TTs, this identified process successively functions as four aryl C–H bonds.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c00302