Maternal-fetal toxicity of Strychnos pseudoquina extract treatment during pregnancy

Plants and herbs have been used by women throughout history for therapeutic purposes. Strychnos pseudoquina, a plant used in the treatment of various diseases, can also function as an abortive herb. There is no scientific confirmation of its effects during pregnancy, and the activity of this plant n...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2023-07, Vol.311, p.116459-116459, Article 116459
Main Authors: Souza, Maysa Rocha, Brito, Evelyn Caroline Barbosa, Furtado, Linne Stephane, Barco, Vinícius Soares, Cruz, Larissa Lopes da, Moraes-Souza, Rafaianne Queiroz, Monteiro, Gean Charles, Lima, Giuseppina Pace Pereira, Damasceno, Débora Cristina, Volpato, Gustavo Tadeu
Format: Article
Language:English
Subjects:
Abortifacient Agents
abortifacients
Abortion
Animals
bark
blastocyst
Body Weight
body weight changes
bone formation
embryo implantation
Female
fetal development
food intake
kidneys
liver
Malformations
Medicinal plants
Plant Extracts - pharmacology
Pregnancy
Rats
Rats, Wistar
reproductive toxicology
S. pseudoquina
Strychnos
therapeutics
toxicity
traditional medicine
Uterus
Water
Weight Gain
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Summary:Plants and herbs have been used by women throughout history for therapeutic purposes. Strychnos pseudoquina, a plant used in the treatment of various diseases, can also function as an abortive herb. There is no scientific confirmation of its effects during pregnancy, and the activity of this plant needs to be substantiated or refuted with experimental evidence. Evaluating the effect of the S. pseudoquina aqueous extract on maternal reproductive toxicity and fetal development. The aqueous extract of S. pseudoquina bark was evaluated in Wistar rats. Pregnant rats were distributed into four experimental groups (n = 12 rats/group): Control = treated with water (vehicle); Treated 75, Treated 150, and Treated 300 = treated with S. pseudoquina at dose 75, 150 and 300 mg/kg, respectively. The rats were treated by an intragastric route (gavage) from day 0 to day 21 of pregnancy. At the end of pregnancy, maternal reproductive outcomes, organs, biochemical and hematological profiles, fetuses, and placentas were analyzed. Maternal toxicity was evaluated through body weight gain, water, and food intake. With knowledge of the harmful dosage of the plant, other rats were used on gestational day 4 for the evaluation of morphological analyses before embryo implantation. P 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2023.116459