Elasticity of Swollen and Folded Polyacrylamide Hydrogel Using the MARTINI Coarse-Grained Model

• Published in: ACS applied materials & interfaces 2025-01
• Main Authors: Rho, Seunghyok, Koh, Heeyuen, Yu, Ji Woong, Koo, Hye Been, Kim, Sebin, Jung, Je-Yeon, Jung, EunYeong, Nam, Chongyong, Lee, Jae Young, Jeon, Kyounghwa, Chang, Jae-Byum, Kim, Do-Nyun, Lee, Won Bo
• Format: Article
• Language: English
• ISSN: 1944-8252; 1944-8252
• DOI: 10.1021/acsami.4c18162

One of the key advantages of using a hydrogel is its superb control over elasticity obtained through variations of constituent polymer and water. The underlying molecular nature of a hydrogel is a fundamental origin of hydrogel mechanics. In this article, we report a Polyacrylamide (PAAm)-based hydrogel model using the MARTINI coarse-grained (CG) force field. The MARTINI hydrogel is molecularly developed through Iterative Boltzmann inversion (IBI) using all-atom molecular dynamics (AAMD), and its quality is evaluated through the experimental realization of the target hydrogel. The developed model offers a mechanically high-fidelity CG hydrogel that can access large-scale water-containing hydrogel behavior, which is difficult to explore through AAMD in practical time. With the modeled hydrogel, we reveal that the polymer conformation modulates the elasticity of the hydrogel from a folded state to a swollen state, confirmed by the Panyukov model. The results provide a robust bridge for linking the polymer conformations and alignment to their bulk deformation, enabling the multifaceted and material-specific predictions required for hydrogel applications.