Interactions between nanoparticle corona proteins and the immune system

The corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. No...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in biotechnology 2023-12, Vol.84, p.103010-103010, Article 103010
Main Authors: Tran, Trieu TM, Roffler, Steve R
Format: Article
Language:English
Subjects:
antibodies
apolipoproteins
biotechnology
blood serum
complement
hypersensitivity
Immune System
immunoglobulins
Nanomedicine
Nanoparticles
polyethylene glycol
Proteins
Severe acute respiratory syndrome coronavirus 2
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. Notably, it highlights the latest findings on the generation of antibody responses to the polyethylene glycol (PEG) component of SARS-CoV-2 mRNA vaccines and possible mechanisms of hypersensitivity reactions induced by antibodies that bind to NPs. Finally, we briefly outline how the NP interactions with immune cells can be harnessed to enhance targeted delivery of nanocargos to disease sites. [Display omitted] •Natural IgG antibodies can bind to NPs and activate complement.•SARS-CoV-2 mRNA vaccines increase the titers of anti-PEG antibodies in recipients.•Anti-PEG antibodies can destabilize lipid nanocarriers to release their payloads.•IgG antibodies binding to NPs can activate innate immune cells and induce hypersensitivity reactions.•Innate immune cells can be enlisted to help deliver NPs to disease sites.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2023.103010