Authentication of Radix Aucklandiae and its substitutes by GC-MS and hierarchical clustering analysis

Radix Aucklandiae (Muxiang in Chinese), the dried root of Aucklandia lappa, is used as a medicinal material for digestive system disorders in traditional Chinese medicine for centuries. Owing to the similarity of morphologies and trade names, Radix Vladimiriae (Chuan-Muxiang), the roots of Vladimiri...

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Bibliographic Details
Published in:Journal of separation science 2007-12, Vol.30 (18), p.3233-3239
Main Authors: Shum, Ka-Chiu, Chen, Feng, Li, Song-Lin, Wang, Jun, But, Paul Pui-Hay, Shaw, Pang-Chui
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Chemical industry and chemicals
Cluster Analysis
Essential oils, perfumes
Exact sciences and technology
Gas Chromatography-Mass Spectrometry - methods
GC-MS
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Radix Aladimiriae
Radix Aristolochiae
Radix Aucklandiae
Radix Inulae
Ranunculaceae - chemistry
Ranunculaceae - classification
Reproducibility of Results
Washing products. Cosmetics and toiletries. Perfumes
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Summary:Radix Aucklandiae (Muxiang in Chinese), the dried root of Aucklandia lappa, is used as a medicinal material for digestive system disorders in traditional Chinese medicine for centuries. Owing to the similarity of morphologies and trade names, Radix Vladimiriae (Chuan-Muxiang), the roots of Vladimiria souliei and V. souliei var. cinerea, and Radix Inulae (Tu-Muxiang), the roots of Inula helenium and Inula racemosa, as well as the renal toxic aristolochic acid containing Radix Aristolochiae (Qing-Muxiang), the roots of Aristolochia debilis and Aristolochia contorta, are often used confusedly as the substitutes of Radix Aucklandiae. In order to ensure the effective and safe utility of Radix Aucklandiae, a GC-MS method was developed to generate the chemical profiles of essential oils of Radix Aucklandiae and its substitutes. In addition, hierarchical clustering analysis was used to compare the similarities of these chemical profiles. It was found that all the samples of A. lappa have similar chemical profiles and were clustered into one group, while the samples of Radix Vladimiriae, Radix Inulae, and Radix Aristolochiae were clustered into their own independent groups, respectively, suggesting that together with hierarchical clustering analysis, chemical profiles of essential oils generated by GC-MS could objectively discriminate Radix Aucklandiae from its common substitutes.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.200700232