Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner

Acetylsalicylic acid (ASA) can exert proanaphylactic effects, but the extent of this phenomenon and its underlying mechanisms are undefined. Yet, low homeostatic prostaglandin E2 (PGE2) levels have been associated with anaphylaxis. In this study, we investigated whether the proanaphylactic effect of...

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Bibliographic Details
Published in:The Journal of clinical investigation 2025-03, Vol.135 (5)
Main Authors: Globig, Philipp, Morakabati, Payam, Höfer, Veronika, Willmes, Diana M., Babina, Magda, Worm, Margitta
Format: Article
Language:English
Subjects:
Adult
Anaphylaxis - chemically induced
Anaphylaxis - genetics
Anaphylaxis - immunology
Anaphylaxis - metabolism
Anaphylaxis - pathology
Animals
Aspirin - adverse effects
Aspirin - pharmacology
Dinoprostone - genetics
Dinoprostone - immunology
Dinoprostone - metabolism
Female
Humans
Inflammation
Male
Mice
Mice, Knockout
Middle Aged
Receptors, Prostaglandin E, EP2 Subtype - genetics
Receptors, Prostaglandin E, EP3 Subtype - genetics
Receptors, Prostaglandin E, EP4 Subtype - genetics
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