7 I, a structurally modified sinomenine, exerts dual anti‐GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

Background and Purpose Glioblastoma multiforme (GBM) is an aggressive brain tumour which drug treatment has no overall significant effect on survival rate. Sinomenine is a natural product extracted from the traditional Chinese medicine Qingteng and was found to have a certain anti‐tumour effect. Alt...

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Bibliographic Details
Published in:British journal of pharmacology 2025-05, Vol.182 (10), p.2310-2331
Main Authors: Yang, Hong, Jiang, Bin, Li, Wan, Du, Guanhua, Xu, Fang, Zhang, Yizhi, Yang, Yihui, Zhang, Sen, Cao, Wanxin, Li, Xiaoxue, Zhang, Xu, Ji, Tengfei, Wang, Jinhua
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Brain Neoplasms - drug therapy
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Cell Death - drug effects
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
GBM
Glioblastoma - drug therapy
Glioblastoma - metabolism
Glioblastoma - pathology
Humans
lysosomal membrane permeabilization
Lysosomes - drug effects
Lysosomes - metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
Morphinans - chemistry
Morphinans - pharmacology
Morphinans - therapeutic use
necroptosis
Necroptosis - drug effects
Sinomenine derivatives
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