De novo non-canonical nanopore basecalling enables private communication using heavily-modified DNA data at single-molecule level

Hidden messages in DNA molecules by employing chemical modifications has been suggested for private data storage and transmission at high information density. However, rapidly decoding these “molecular keys” with corresponding basecallers remains challenging. We present DeepSME, a nanopore sequencin...

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Bibliographic Details
Published in:Nature communications 2025-05, Vol.16 (1), p.4099-11, Article 4099
Main Authors: Fan, Qingyuan, Zhao, Xuyang, Li, Junyao, Liu, Ronghui, Liu, Ming, Feng, Qishun, Long, Yanping, Fu, Yang, Zhai, Jixian, Pan, Qing, Li, Yi
Format: Article
Language:English
Subjects:
38/77
45/23
5-Methylcytosine - analogs & derivatives
5-Methylcytosine - chemistry
631/114/1305
631/114/2397
631/1647/48
631/61/514/1948
Bioengineering
Data storage
Data transmission
Decoding
Deep Learning
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
DNA Methylation
Edge computing
Humanities and Social Sciences
Ion currents
Messages
multidisciplinary
Nanopore Sequencing - methods
Nanopores
Nucleotides
Privacy
Science
Science (multidisciplinary)
Sequence Analysis, DNA - methods
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