Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo

Alzheimer’s disease (AD) is initiated by amyloid-beta (Aβ) accumulation in the neocortex; however, the cortical layers and neuronal cell types first susceptible to Aβ remain unknown. Using in vivo two-photon Ca2+ imaging in the visual cortex of AD mouse models, we found that cortical layer 5 neurons...

Full description

Saved in:

Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Mass.), 2025-07, Vol.113 (14), p.2265-2279.e7
Main Authors:	Papanikolaou, Amalia, Graykowski, David, Lee, Byung Il, Yang, Mengke, Ellingford, Robert, Zünkler, Jana, Bond, Suraya A., Rowland, James M., Rajani, Rikesh M., Harris, Samuel S., Sharp, David J., Busche, Marc Aurel
Format:	Article
Language:	English
Subjects:	Action Potentials - physiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer’s disease Amyloid beta-Peptides - metabolism amyloid-beta Animals C-Reactive Protein - metabolism deep cortical layers Disease Models, Animal GluA4 Humans Interneurons - metabolism Interneurons - pathology Interneurons - physiology Male Mice Mice, Transgenic Nerve Tissue Proteins - metabolism neuronal pentraxin 2 Neuropixels parvalbumin interneurons Parvalbumins - metabolism selective vulnerability two-photon Ca2+ imaging visual cortex Visual Cortex - metabolism Visual Cortex - pathology Visual Cortex - physiopathology
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!