Surface lipoprotein sorting by crosstalk between Lpt and Lol pathways in gram-negative bacteria

Lipopolysaccharide (LPS) and lipoprotein, two essential components of the outer membrane (OM) in Gram-negative bacteria, play critical roles in bacterial physiology and pathogenicity. LPS translocation to the OM is mediated by LptDE, yet how lipoproteins sort to the cell surface remains elusive. Her...

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Bibliographic Details
Published in:	Nature communications 2025-05, Vol.16 (1), p.4357-14, Article 4357
Main Authors:	Luo, Qingshan, Wang, Chengai, Qiao, Shuai, Yu, Shan, Chen, Lianwan, Kim, Seonghoon, Wang, Kun, Zheng, Jiangge, Zhang, Yong, Wu, Fan, Lei, Xiaoguang, Lou, Jizhong, Hennig, Michael, Im, Wonpil, Miao, Long, Zhou, Min, Bei, Weiwei, Huang, Yihua
Format:	Article
Language:	English
Subjects:	101/1 101/58 631/326 631/326/41/2536 631/45/612/1237 631/535/1266 82/80 82/83 ATP-Binding Cassette Transporters Bacteria Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial physiology Cell surface Crystal structure Crystallography, X-Ray E coli Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gram-negative bacteria Gram-Negative Bacteria - metabolism Humanities and Social Sciences Immunofluorescence Lipopolysaccharides Lipopolysaccharides - metabolism Lipoproteins Lipoproteins - chemistry Lipoproteins - genetics Lipoproteins - metabolism Mass spectrometry Mass spectroscopy Models, Molecular multidisciplinary Pathogenicity Protein Transport Pseudomonas aeruginosa - metabolism Science Science (multidisciplinary) Translocation
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