Effects of NMDA receptor antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit

Working memory relies on synchronised network oscillations involving complex interplay between pyramidal cells and GABAergic interneurons. NMDA receptor (NMDAR) antagonists influence both network oscillations and working memory, but the relationship between these two consequences has not been elucid...

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Published in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2025-12, Vol.50 (13), p.1938-1948
Main Authors: Vinnakota, Chitra, Hudson, Matthew R., Ikeda, Kazutaka, Ide, Soichiro, Mishina, Masayoshi, Sundram, Suresh, Jones, Nigel C., Hill, Rachel Anne
Format: Article
Language:English
Subjects:
631/378/1595/1636
631/378/87
Animals
Antidepressants
Behavioral Sciences
Biological Psychology
Cognition & reasoning
Dizocilpine
Dizocilpine Maleate - pharmacology
Electrophysiological recording
Excitatory Amino Acid Antagonists - pharmacology
Gamma Rhythm - drug effects
Gamma Rhythm - physiology
Genotypes
Glutamate receptors
Glutamic acid receptors (ionotropic)
Hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Interactive computer systems
Interneurons
Ketamine
Ketamine - pharmacology
Male
Medicine
Medicine & Public Health
Memory
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Mental task performance
Mice
Mice, Inbred C57BL
Mice, Knockout
N-Methyl-D-aspartic acid receptors
Neurosciences
Oscillations
Pharmacotherapy
Phencyclidine
Phencyclidine - pharmacology
Prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiology
Psychiatry
Psychotropic drugs
Pyramidal cells
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - genetics
Receptors, N-Methyl-D-Aspartate - metabolism
Receptors, N-Methyl-D-Aspartate - physiology
Schizophrenia
Verbal learning
γ-Aminobutyric acid
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