Expanding the genetic code: Strategies for noncanonical amino acid incorporation in biopolymer

[Display omitted] •Functional diversity of proteins can be enhanced by incorporating ncAAs.•In vivo ncAA incorporation requires blank codon and orthogonal tRNA/aaRS pair.•The amber stop codon, UAG was initially utilized as a blank codon.•Quadruplet codons, and compressed sense codons were used to se...

Full description

Saved in:

Bibliographic Details
Published in:	Bioresource technology 2025-09, Vol.432, p.132691, Article 132691
Main Authors:	Kim, Donghyeon, Sung, Doeon, Lee, Jeong Wook
Format:	Article
Language:	English
Subjects:	amino acids Amino Acids - genetics Amino Acids - metabolism Biopolymer biopolymers Biopolymers - metabolism biosynthesis biotechnology Biotechnology - methods Codon - genetics Codon, Terminator - genetics functional diversity genetic code Genetic Code - genetics Genetic code expansion Non-canonical amino acid Orthogonal translation stop codon Synthetic biology
Citations:	Items that this one cites
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!