Metabolic dysfunction-associated steatohepatitis treated by poly(ethylene glycol)-block-poly(cysteine) block copolymer-based self-assembling antioxidant nanoparticles

Non-alcoholic steatohepatitis (NASH), now known as metabolic dysfunction-associated steatohepatitis (MASH), involves oxidative stress caused by the overproduction of reactive oxygen species (ROS). Small-molecule antioxidants have not been approved for antioxidant chemotherapy because of severe adver...

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Bibliographic Details
Published in:	Journal of controlled release 2024-06, Vol.370, p.367-378
Main Authors:	Koda, Yuta, Nagasaki, Yukio
Format:	Article
Language:	English
Subjects:	Animals Antioxidant therapy Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacology Block copolymer micelles Cysteine Cysteine - administration & dosage Cysteine - chemistry drug therapy fatty liver fibrosis homeostasis Humans inflammation lipids Liver - drug effects Liver - metabolism Male Metabolic dysfunction-associated steatohepatitis (MASH) Mice Mice, Inbred C57BL Nanoparticles Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Oxidative stress Oxidative Stress - drug effects Peptides - administration & dosage Peptides - chemistry Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry polymers reactive oxygen species Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism thiols
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