Plasma NfL, GFAP, and pTau181 in patients with isolated REM sleep behavior disorder

Abstract Study Objectives Idiopathic/isolated Rapid Eye Movement (REM) sleep behavior disorder (iRBD) is recognized as a prodromal stage of neurodegenerative diseases, particularly of α-synucleinopathies. The development of blood-based biomarkers enables the in vivo assessment of neuronal, glial, an...

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Published in:SLEEP 2025-12, Vol.48 (12), p.1
Main Authors: Liguori, Claudio, Fernandes, Mariana, Zatti, Cinzia, Carpi, Matteo, Tolassi, Chiara, Testone, Greta, Cirillo, Flavia, Antonucci, Matteo, Bergamo, Giusy, Risino, Irene, Benedetti, Riccardo, Caon, Desirèe, Quaresima, Virginia, Galli, Alice, Rizzardi, Andrea, Girotto, Irene, Trasciatti, Chiara, Lupini, Alessandro, Eshja, Klaudia, Giliani, Silvia, Padovani, Alessandro, Mercuri, Nicola Biagio, Pilotto, Andrea
Format: Article
Language:English
Subjects:
Advertising executives
Aged
Alzheimer Disease - blood
Alzheimer's disease
Behavior disorders
Biomarkers
Biomarkers - blood
Care and treatment
Comparative analysis
Cross-Sectional Studies
Disease
Ethylenediaminetetraacetic acid
Female
Glial Fibrillary Acidic Protein - blood
Humans
Male
Medical research
Medicine, Experimental
Mental illness
Middle Aged
Nervous system diseases
Neurodegeneration
Neurofilament Proteins - blood
Phosphorylation
Plasma
REM sleep
REM Sleep Behavior Disorder - blood
Sleep
tau Proteins - blood
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